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11/09/2021
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Số lượt xem PDF: 184
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Ngoc Tuan, N. ., Tran Ngoc Tu, N. ., & Tien Dung, N. . (2021). AUTOLOGOUS PLATELET - RICH PLASMA (PRP) THERAPY AND CHANGEMENTS OF TOPICAL BIOLOGICAL MARKERS (EGF, VEGF AND MMP12) OF CHRONIC WOUNDS . Tạp Chí Y học Việt Nam, 506(1-2). https://doi.org/10.51298/vmj.v506i1-2.973
AUTOLOGOUS PLATELET - RICH PLASMA (PRP) THERAPY AND CHANGEMENTS OF TOPICAL BIOLOGICAL MARKERS (EGF, VEGF AND MMP12) OF CHRONIC WOUNDS
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Tóm tắt
Objective: Our aim was to evaluate topical EGF, VEGF, MMP12 concentrations of chronic wounds which after Autologous Platelet - Rich Plasma(PRP) therapy.
Methods: The study conducted a descriptive longitudinal study at the Wound Healing Center of the Vietnam National Burn Hospital from 11/2018 to 2/2020. 24 patients with chronic wounds and aged 18 years old or older were enrolled in this study. These patients were injected autologous PRP at wound bed. We biopsied chronic wound bed tissue for evaluating EGF, VEGF and MMP12 by the Elisa technique at the first, second and third week of follow-up.
Results: After PRP therapy, topical EGF and VEGF concentration increased after 1 week of treatment. MMP12 concentraiton significantly reduced compaired to before PRP therapy.
Conclusion: In addition to PRP therapy had a beneficial effect on cutaneous regeneration and wound healing of the chronic wound. The autologous PRP promoted the wound healing process byincreating topical EGF and VEGF, reducing MMP12 which known as a pro-inflammatiory mediator.
Chi tiết bài viết
Từ khóa
Platelet - Rich Plasma, EGF, VEGF, MMP12, Chronic wound
Tài liệu tham khảo
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2. Menke N.B., Ward K.R., Witten T.M., Bonchev D.G., Diegelmann R.F. (2007); “Impaired wound healing”. ClinDermatol. 2007, 25:19-25
3. Dowsett C.(2015); “Breaking the cycle of hard-to-heal wounds: balancing cost and care”. Wounds International 2015, Vol 6 Issue 2
4. Marta Otero-Viñas and Vincent Falanga (2016); “Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy”. Adv Wound Care (New Rochelle) 2016, Apr 1; 5(4): 149-163.
5. Banfi G.(2012); “Platelet rich plasma”. Journal of biological regulators and homeostatic agents 2012;26, 1.
6. Amable P.R., Carias, R.B., Teixeira, M.V., da Cruz Pacheco, I., Correa do Amaral R.J., Granjeiro J.M. and Borojevic R. (2013); “Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors”. Stem cell research & therapy , 2013, 4 (3): 67
7. Elena Conde-Montero, Pablo de la CuevaDobao, José MaríaMartínez González (2017) ; “Platelet-rich plasma for the treatment of chronic wounds: evidence to date”. Chronic Wound Care Management and Research. 2017, Vol 2017:4 107-120
8. KristerJärbrink, Gao Ni, Henrik Sönnergren, ArturSchmidtchen, Caroline Pang, Ram Bajpai and Josip Ca (2016); “Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review”. Syst Rev. 2016; 5(1): 152
9. National Pressure Ulcer Advisory Panel (NPUAP)(2016); Pressure Injury Stages, http://www.npuap.org/, 2016.
10. Vladimir N. Obolenskiy, Darya A. Ermolova, Leonid A. Laberko (2014); “Efficacy of platelet - rich plasma for the treatment of chronic wounds”. The EWMA Journal, volume 14, No 1, April, 2014, p. 37-40.
11. Mehrannia M., Vaezi M., Yousefshahi F., Rouhipour N (2014); “Platelet rich plasma for treatment of nonhealing diabetic foot ulcers:a case report”. CJD (canadian journal of diabetes), February 2014, Volume 38, Issue 1, Pages 5 - 8.
12. Javier Ramos-Torrecillas, Elvira De Luna-Bertos, Olga García-Martínez (2014); “Clinical Utility of Growth Factors and Platelet-Rich Plasma in Tissue Regeneration: A Review”. Wounds. 2014; 26(7):207-213
13. Diegelmann R.F. and Evans M.C (2020); “Wound Healing: An Overview of acute, fibronetic and delayed healing”. Frontiers in Bioscience 9, 283-289
14. George Han and Roger Ceilley (2017);“Chronic Wound Healing: A Review of Current Management and Treatments”. AdvTher. 2017; 34(3): 599-610.
15. Sabine Werner and Richard (2003); Regulation of Wound Healing by Growth Factors and Cytokines; GrosPhysiol Rev 83: 835-870, 2003;
16. Stephan Barrientos; OliveraStojadinovic, Michael S. Golinko, Harold Brem, MarjanaTomic-Canic (2008), Growth factors and cytokines in wound healing; Wound Repair and Regeneration Wound, (2008), 16, 585-601
17. Hart J. (2002); Inflammation. 1: Its role in the healing of acute wounds. J Wound Care. 2002 Jun; 11(6):205-9.
18. Zhang Y, Wang T, Dong J (2016); Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis. Wound J. 2016 Jun; 13(3): 354-66.
19. ShoYamakawa & Kenji Hayashida (2019), Advances in surgical applications of growth factors for wound healing; Burns & Trauma, volume 7, Article number: 10 (2019).
20. Park JW, Hwang SR, Yoon IS (2017); Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017; 22:E1259.
21. Nanney LB (1990); Epidermal and dermal effects of epidermal growth factor during wound repair. J Invest Dermatol. 1990; 94:624-9.
22. J.Hardwicke, D.Schmaljohann, D.Boyce, D.Thomas (2008); Epidermal growth factor therapy and wound healing — past, present and future perspectives; The Surgeon Volume 6, Issue 3, June 2008, Pages 172-177
23. Brown GL, Curtsinger LJ, White M, Mitchell RO, Pietsch J, Nordquist R, et al. (1988); Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann Surg. 1988; 208:788-94.
24. Kelly E. Johnson and Traci A. Wilgus (2014); Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair; Adv Wound Care. 2014 Oct 1; 3(10): 647-661.
25. Thittamaranahalli Muguregowda Honnegowda, Pramod Kumar, Echalasara Govindarama Padmanabha Udupa, Sudesh Kumar, Udaya Kumar, Pragna Rao (2015); Role of angiogenesis and angiogenic factors in acute and chronic wound healing; Plast Aesthet Res 2015; 2:243-249
26. George Han and Roger Ceilley (2017); Chronic Wound Healing: A Review of Current Management and Treatments; Adv Ther. 2017; 34(3): 599-610.
27. Robert Nunan, Harding K. G. and Martin P. (2014); “Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity”; Disease Models & Mechanisms 7, 1205-1213
28. Amit Kuma Srivastava, PiushKhare, NavdeepRaghuwanshi et al (2016); Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases. Curr Protein Pept Sci. 2016; 17(6):596-602
29. Guilherme F. Caetano, MarcioFronza, Marcel N. Leite, Ary Gomes &Marco Andrey Cipriani Frade (2016); Comparison of collagen content in skin wounds evaluated by biochemical assay and by computer-aided histomorphometric analysis; Pharm Biol. 2016 Nov; 54(11):2555-2559
30. Tatiana N. Demidova-Rice, Lindsey Wolf, Jeffry Deckenback, Michael R. Hamblin, Ira M. Herman (2012). “Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In vivo”. PLOS. https://doi.org/10.1371/journal.pone.0032146
31. Krister Järbrink, Gao Ni, Henrik Sönnergren, Artur Schmidtchen, Caroline Pang, Ram Bajpai and Josip Ca (2016);“Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review”. Syst Rev. 2016; 5(1): 152
32. Verma RP, Hansch C (March 2007); "Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs". Bio org. Med. Chem. 15 (6): 2223-68.
33. Mikel Aristorena, Eunate Gallardo-Vara, MatejVicen et al. (2019); MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells; Int. J. Mol. Sci. 2019, 20, 3107;
34. Marie Wolf, Inna Maltseva, Selene M. Clay, Peipei Pan, Abhinay Gajjala and Matilda F. Chan (2017); Effects of MMP12 on cell motility and inflammation during corneal epithelial repair; Exp Eye Res. 2017 Jul; 160: 11-20.
35. Manish Suthar, Saniya Gupta, SuhailBukhari and Venkatesh Ponemone (2017); Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series. J Biomed Sci. 2017; 24: 16
36. Hamilton B., Tol J.L. Knez W. and Chalabi H. (2013); “Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment”. British journal of sports medicine, 2015 Jul;49(14):957-60
37. Marx R.E (2004). “Platelet-rich plasma: evidence to support its use”. J Oral axillo fac Surg. 2004. 62:489-496
2. Menke N.B., Ward K.R., Witten T.M., Bonchev D.G., Diegelmann R.F. (2007); “Impaired wound healing”. ClinDermatol. 2007, 25:19-25
3. Dowsett C.(2015); “Breaking the cycle of hard-to-heal wounds: balancing cost and care”. Wounds International 2015, Vol 6 Issue 2
4. Marta Otero-Viñas and Vincent Falanga (2016); “Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy”. Adv Wound Care (New Rochelle) 2016, Apr 1; 5(4): 149-163.
5. Banfi G.(2012); “Platelet rich plasma”. Journal of biological regulators and homeostatic agents 2012;26, 1.
6. Amable P.R., Carias, R.B., Teixeira, M.V., da Cruz Pacheco, I., Correa do Amaral R.J., Granjeiro J.M. and Borojevic R. (2013); “Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors”. Stem cell research & therapy , 2013, 4 (3): 67
7. Elena Conde-Montero, Pablo de la CuevaDobao, José MaríaMartínez González (2017) ; “Platelet-rich plasma for the treatment of chronic wounds: evidence to date”. Chronic Wound Care Management and Research. 2017, Vol 2017:4 107-120
8. KristerJärbrink, Gao Ni, Henrik Sönnergren, ArturSchmidtchen, Caroline Pang, Ram Bajpai and Josip Ca (2016); “Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review”. Syst Rev. 2016; 5(1): 152
9. National Pressure Ulcer Advisory Panel (NPUAP)(2016); Pressure Injury Stages, http://www.npuap.org/, 2016.
10. Vladimir N. Obolenskiy, Darya A. Ermolova, Leonid A. Laberko (2014); “Efficacy of platelet - rich plasma for the treatment of chronic wounds”. The EWMA Journal, volume 14, No 1, April, 2014, p. 37-40.
11. Mehrannia M., Vaezi M., Yousefshahi F., Rouhipour N (2014); “Platelet rich plasma for treatment of nonhealing diabetic foot ulcers:a case report”. CJD (canadian journal of diabetes), February 2014, Volume 38, Issue 1, Pages 5 - 8.
12. Javier Ramos-Torrecillas, Elvira De Luna-Bertos, Olga García-Martínez (2014); “Clinical Utility of Growth Factors and Platelet-Rich Plasma in Tissue Regeneration: A Review”. Wounds. 2014; 26(7):207-213
13. Diegelmann R.F. and Evans M.C (2020); “Wound Healing: An Overview of acute, fibronetic and delayed healing”. Frontiers in Bioscience 9, 283-289
14. George Han and Roger Ceilley (2017);“Chronic Wound Healing: A Review of Current Management and Treatments”. AdvTher. 2017; 34(3): 599-610.
15. Sabine Werner and Richard (2003); Regulation of Wound Healing by Growth Factors and Cytokines; GrosPhysiol Rev 83: 835-870, 2003;
16. Stephan Barrientos; OliveraStojadinovic, Michael S. Golinko, Harold Brem, MarjanaTomic-Canic (2008), Growth factors and cytokines in wound healing; Wound Repair and Regeneration Wound, (2008), 16, 585-601
17. Hart J. (2002); Inflammation. 1: Its role in the healing of acute wounds. J Wound Care. 2002 Jun; 11(6):205-9.
18. Zhang Y, Wang T, Dong J (2016); Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis. Wound J. 2016 Jun; 13(3): 354-66.
19. ShoYamakawa & Kenji Hayashida (2019), Advances in surgical applications of growth factors for wound healing; Burns & Trauma, volume 7, Article number: 10 (2019).
20. Park JW, Hwang SR, Yoon IS (2017); Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017; 22:E1259.
21. Nanney LB (1990); Epidermal and dermal effects of epidermal growth factor during wound repair. J Invest Dermatol. 1990; 94:624-9.
22. J.Hardwicke, D.Schmaljohann, D.Boyce, D.Thomas (2008); Epidermal growth factor therapy and wound healing — past, present and future perspectives; The Surgeon Volume 6, Issue 3, June 2008, Pages 172-177
23. Brown GL, Curtsinger LJ, White M, Mitchell RO, Pietsch J, Nordquist R, et al. (1988); Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann Surg. 1988; 208:788-94.
24. Kelly E. Johnson and Traci A. Wilgus (2014); Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair; Adv Wound Care. 2014 Oct 1; 3(10): 647-661.
25. Thittamaranahalli Muguregowda Honnegowda, Pramod Kumar, Echalasara Govindarama Padmanabha Udupa, Sudesh Kumar, Udaya Kumar, Pragna Rao (2015); Role of angiogenesis and angiogenic factors in acute and chronic wound healing; Plast Aesthet Res 2015; 2:243-249
26. George Han and Roger Ceilley (2017); Chronic Wound Healing: A Review of Current Management and Treatments; Adv Ther. 2017; 34(3): 599-610.
27. Robert Nunan, Harding K. G. and Martin P. (2014); “Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity”; Disease Models & Mechanisms 7, 1205-1213
28. Amit Kuma Srivastava, PiushKhare, NavdeepRaghuwanshi et al (2016); Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases. Curr Protein Pept Sci. 2016; 17(6):596-602
29. Guilherme F. Caetano, MarcioFronza, Marcel N. Leite, Ary Gomes &Marco Andrey Cipriani Frade (2016); Comparison of collagen content in skin wounds evaluated by biochemical assay and by computer-aided histomorphometric analysis; Pharm Biol. 2016 Nov; 54(11):2555-2559
30. Tatiana N. Demidova-Rice, Lindsey Wolf, Jeffry Deckenback, Michael R. Hamblin, Ira M. Herman (2012). “Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In vivo”. PLOS. https://doi.org/10.1371/journal.pone.0032146
31. Krister Järbrink, Gao Ni, Henrik Sönnergren, Artur Schmidtchen, Caroline Pang, Ram Bajpai and Josip Ca (2016);“Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review”. Syst Rev. 2016; 5(1): 152
32. Verma RP, Hansch C (March 2007); "Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs". Bio org. Med. Chem. 15 (6): 2223-68.
33. Mikel Aristorena, Eunate Gallardo-Vara, MatejVicen et al. (2019); MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells; Int. J. Mol. Sci. 2019, 20, 3107;
34. Marie Wolf, Inna Maltseva, Selene M. Clay, Peipei Pan, Abhinay Gajjala and Matilda F. Chan (2017); Effects of MMP12 on cell motility and inflammation during corneal epithelial repair; Exp Eye Res. 2017 Jul; 160: 11-20.
35. Manish Suthar, Saniya Gupta, SuhailBukhari and Venkatesh Ponemone (2017); Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series. J Biomed Sci. 2017; 24: 16
36. Hamilton B., Tol J.L. Knez W. and Chalabi H. (2013); “Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment”. British journal of sports medicine, 2015 Jul;49(14):957-60
37. Marx R.E (2004). “Platelet-rich plasma: evidence to support its use”. J Oral axillo fac Surg. 2004. 62:489-496