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Ngày xuất bản: 11/09/2021
Số lượt xem tóm tắt: 273
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DOI: https://doi.org/10.51298/vmj.v506i1-2.988
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Tập 506 Số 1-2 (2021): Vietnam Medical Journal
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Duy Thang, N. ., Thi Thuy Hoa, P. ., Thi Dieu Ngan, P. ., Nhat Hoang, N. ., & Thi Cam Ha, C. . (2021). MESENCHYMAL STEM CELL-BASED THERAPY FOR CHRONIC KIDNEY FAILURE RELATING LUPUS ERYTHEMATOSUS - A CASE REPORT. Tạp Chí Y học Việt Nam, 506(1-2). https://doi.org/10.51298/vmj.v506i1-2.988

MESENCHYMAL STEM CELL-BASED THERAPY FOR CHRONIC KIDNEY FAILURE RELATING LUPUS ERYTHEMATOSUS - A CASE REPORT

Duy Thang Nguyen 1, Thi Thuy Hoa Phan 1, Thi Dieu Ngan Phan 2, Nhat Hoang Ngo 2, Thi Cam Ha Che 2,
1 Hue Central Hospital
2 Hue University

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Tóm tắt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, which is characterized by systemic multiple-organ involvement, relapses with large amount of autoantibodies. Their pathophysiology is multifaceted, involves complex hormonal-immunological-cellular interactions, and leads to damage in multiple cell types, which is often resistant to conventional therapy. Thus, novel strategies are needed to repair the renal parenchyma and preserve kidney function. Mesenchymal stem cells (MSC) confer renal protection through paracrine/endocrine effects, and to some degree possibly by direct engraftment. The patient was diagnosed with chronic kidney disease by standard methods for more than fifteen years. The patient agreed to the treatment of autologous adipose mesenchymal stem cell transplantation. The adipose mesenchymal stem cells were harvested by surgery, isolated with our enzyme protocol. The patient received one injection with 2,6x106 cells/kg for a total of 43kg of body weight. The patient with SLE do not receive prompt treatment, he get irreversible organ damage. After seven months, the preexisting renal insufficiency gradually ameliorated, including the decrease of creatinine and blood urea as well as the increase of estimated glomerular filtration rate. Lupus symptoms also reduced, followed by the improvement of body movement and medication reduction.There was insufficient evidence of the clinical setting to show the efficiency of mesenchymal stem cells on the lupus nephritis relating to chronic kidney disease.  This clinical trial highlights the feasibility and safety of mesenchymal stem cell treatments in renal failure-associated- autoimmune diseases.

Chi tiết bài viết

Từ khóa

Mesenchymal stem cells, adipose tissue, chronic kidney failure, lupus erythematosus, transplantation, autoimmune disease

Tài liệu tham khảo

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