GIÁ TRỊ CỦA TỈ SỐ LACTATE/ALBUMIN MÁU TRONG TIÊN LƯỢNG TỬ VONG 28 NGÀY Ở BỆNH NHÂN NHIỄM KHUẨN HUYẾT TẠI BỆNH VIỆN THỐNG NHẤT

Abstract

Background: Sepsis is a condition where the body reacts excessively to an infection, leading to life-threatening multi-organ dysfunction. Despite advances in diagnosis and treatment, the mortality rate from sepsis ranges between 40-60%. Blood lactate concentration is a biochemical marker used to assess tissue hypoxia and the severity of infection. Additionally, low blood albumin levels have prognostic value in the context of multi-organ failure. A high lactate/albumin ratio indicates an imbalance between decreased tissue perfusion and malnutrition, aiding in mortality prediction. This study aims to determine the prognostic value of the blood lactate/albumin ratio for 28-day mortality in sepsis patients. Subjects and Methods: This retrospective and prospective cohort study was conducted on 127 sepsis patients at Thong Nhat Hospital from January 2023 to June 2024. Results: The mortality rate was 63%. The median blood lactate/albumin ratio was 2.20. There was a significant difference in the lactate/albumin ratio between the survival and mortality groups (p<0.001). ROC curve analysis showed that the lactate/albumin ratio predicted 28-day mortality with an AUC of 0.81 (95% CI 0.74-0.89; p<0.001), with a cut-off point of 2.69 (sensitivity 55%, specificity 94%). Conclusion: The blood lactate/albumin ratio was higher in the mortality group compared to the survival group and has prognostic value for 28 day mortality in sepsis patients.