ĐẶC ĐIỂM HUYẾT HỌC LÂM SÀNG CỦA BỆNH NHÂN TĂNG BẠCH CẦU ÁI TOAN TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: To describe the hematological characteristics of patients with eosinophilia at the Clinical Hematology Department of the National Children's Hospital from 2019 to 2024. Subjects: A total of 127 patients under 18 years old with at least two peripheral blood tests showing an eosinophil count >1.5G/L, who were followed and treated at the Clinical Hematology Department of the National Children's Hospital from January 2019 to July 2024. Methods: Case series description. Results: The most common hematological clinical symptoms were subcutaneous hemorrhage (23.6%), fever (15.7%), and clinical anemia (12.6%). Eosinophils predominantly infiltrated the skin and gastrointestinal system. Peripheral blood tests showed statistically significant differences (p<0.05) in white blood cell count, eosinophil count, and neutrophil count between the groups with high and very high eosinophil levels. Bone marrow examination revealed differences in the proportion of eosinophil lineage between the two groups. Platelet aggregation tests showed a reduction in aggregation with ADP and collagen in 71.4% of cases. Conclusion: Subcutaneous hemorrhage, fever, and clinical anemia were the most common hematological symptoms. Eosinophils primarily infiltrated the skin and gastrointestinal system. Significant differences were found in peripheral white blood cell counts, eosinophil counts, neutrophil counts, and eosinophil lineage in bone marrow between the high and very high eosinophil groups. Reduced platelet aggregation with ADP, collagen was the predominant finding.