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Date Published: 05/02/2025
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DOI: https://doi.org/10.51298/vmj.v546i3.12781
Issue
Vol. 546 No. 3 (2025)
Section
Các bài báo
How to Cite
Ngô, V. H., Ngô, T. H., Lương, X. H., & Cấn, V. M. (2025). SYNTHESIZE AND EVALUATE THE ANTIBACTERIAL, ANTFUNGAL AND HEMOLYTIC ACTIVITY OF ACTIVE COMPOUND IND-411 DERIVED FROM NATURAL PEPTIDE INDOLICIDIN. Vietnam Medical Journal, 546(3). https://doi.org/10.51298/vmj.v546i3.12781

SYNTHESIZE AND EVALUATE THE ANTIBACTERIAL, ANTFUNGAL AND HEMOLYTIC ACTIVITY OF ACTIVE COMPOUND IND-411 DERIVED FROM NATURAL PEPTIDE INDOLICIDIN

Văn Hoà Ngô, Thu Hằng Ngô, Xuân Huy Lương, Văn Mão Cấn

Main Article Content

Abstract

Objectives: To synthesize and evaluate the potential antimicrobial and antifungal applications of the IND-411 derivative, created based on the structure of Indolicidin. Methods: IND-411 was synthesized using the solid-phase peptide synthesis technique. Its antimicrobial and antifungal activities were assessed using the agar diffusion method, and its hemolytic ability was tested using a hemolysis assay. Results: IND-411 was obtained with a purity of approximately 100%, as determined by high-performance liquid chromatography. Additionally, IND-411 demonstrated better activity against three bacterial strains, E. coli, S. epidermidis, and S. aureus, and the fungus C. albicans, while exhibiting significantly lower hemolytic activity compared to Indolicidin. Conclusion: The IND-411 derivative was successfully synthesized and shows greater potential for antibacterial and antifungal applications than the natural peptide Indolicidin.

Article Details

Keywords

Indolicidin; Antibacterial activity; Hemolysis; Antifungal activity.

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