ĐỐI CHIẾU MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VỚI PHÂN LOẠI MÔ BỆNH HỌC THAI TRỨNG

Abstract

Background: Molar pregnancy is an abnormal pregnancy, most common in Southeast Asia with an incidence of 2-13/1000 pregnancies. Molar pregnancy can progress to trophoblastic neoplasia, which carries a high mortality rate. Currently, there are no studies in Vietnam that combine and compare the clinical characteristics and histopathological classification of molar pregnancies to better understand the diagnostic role of risk factors, ultrasound, and β-hCG levels in the diagnosis of molar pregnancy. Objective: To compare clinical characteristics with histopathological classification of molar pregnancy. Methods: A retrospective, cross-sectional descriptive study was conducted, including 88 molar pregnancy cases at Hung Vuong Hospital from July 2022 to March 2024. The research process involved evaluating clinical characteristics and histopathological classification of molar pregnancy. Data were analyzed using STATA 14.0 software. Results: The study on 88 cases of molar pregnancy revealed an average maternal age of 32.3 years (standard deviation 8.8 years). The average gestational age at diagnosis was 8.5 weeks (standard deviation 2.5 weeks). Of the patients, 29.6% had a history of spontaneous miscarriage, and 3.4% had a history of molar pregnancy. The average pre-curettage β-hCG level was 143,032 mIU/mL. The average time for β-hCG to return to negative was 8 weeks. Ultrasound before curettage identified 64.8% of cases. Histopathological classification showed 15 cases of early-stage complete molar pregnancy (17%), 54 cases of complete molar pregnancy (61.4%), and 19 cases of partial molar pregnancy (21.6%). Conclusion: The study provides an overview of clinical factors related to molar pregnancy, including maternal age, gestational age, obstetric history, β-hCG levels, time for β-hCG to return to negative, and ultrasound findings.