KHẢO SÁT NỒNG ĐỘ ĐỒNG, KẼM, SẮT VÀ TỶ SỐ ĐỒNG/KẼM TRONG HUYẾT TƯƠNG Ở BỆNH NHÂN BỆNH THẬN MẠN

Abstract

Objectives: To determine the levels of plasma copper, zinc, iron and copper/zinc ratio in patients with chronic kidney disease (CKD), and to identify whether these levels correlate to the stages of kidney disease. Methods: The study included 99 patients who were diagnosed with CKD at different stages at Bach-Mai hospital, and 81 healthy control subjects. The plasma levels of copper, zinc, iron and copper/zinc ratio were determined and compared between patient group vs. control, and between CKD stages. Results: The plasma levels of copper, zinc, iron and copper/zinc ratio in CKD were respectively 15,41±6,50 µmol/L, 5,78±2,38 µmol/L, 13,31±5,61 µmol/L, and 2,81±0,82. The plasma zinc and iron levels were significantly decreased, and the plasma copper/zinc ratio were significantly increased in the CKD patient group, in comparison with these ones in the control (p = 0,000). The end-stage renal disease (Stage 5) had a significantly higher plasma copper/zinc ratio than the earlier stages (Stages 2 – 4), correspondingly 3,06±1,00 vs. 2,67±0,68 (p = 0,023). There was a statistically significant relation between the plasma copper/zinc ratio vs. the CKD stage (p = 0,015). Conclusion: The CKD patients have decreased plasma levels of zinc and iron, and increased plasma copper/zinc ratio compared to the control. The copper/zinc ratio increases in later stages of CKD, potentially signaling increased oxidative stress and associated with an increased risk of complications and disease progression.