KẾT HỢP LASER QUANG ĐÔNG VÕNG MẠC VÀ CHẤT KHÁNG YẾU TỐ TĂNG TRƯỞNG NỘI MÔ MẠCH MÁU ĐIỀU TRỊ BỆNH LÝ VÕNG MẠC ĐÁI THÁO ĐƯỜNG TĂNG SINH NGUY CƠ CAO - KẾT QUẢ BƯỚC ĐẦU

Abstract

Background: Proliferative diabetic retinopathy is a severe complication which may result in vision loss on diabetes patients, especially in high-risk patients. Finding out a most effective treatment modality for high-risk proliferative diabetic retinopathy patients is essensial. Purpose: To evaluate preliminary results of combined treatment of laser panretinal photocoagulation and intravitreal injection of anti vascular endothelial growth factor agents on high-risk proliferative diabetic retinopathy patients. Patients and methods: Retrospective, observational case series. Thirty eyes of 19 patients were included in this study. Results: The mean age was 54,4 ± 11,8, male to female ratio was 0,72 : 1 and duration of diabetes was 9,8 ± 6 years. Baseline best-corrected visual acuity (BCVA) was 41,8 ± 19,8 ETDRS letters and baseline central macular thickness was 268,9 ± 37,1 µm; 17 eyes (56,7%) had macular edema. After 3 months of follow-up, BCVA gained 10 ± 9,2 ETDRS letters and CMT decreased 14,9 ± 21,5 µm; the neovascularization regressed completely on 23 eyes (76,7%) and partial on 6 eyes (20%). One eye required vitrectomy due to severe vitreal hemorrhage leading to vitreo-retinal retraction, no significant complication was recorded on treatment procedures. Conclusion: In short term, combined treatment of laser PRP and intravitreal injection of anti-VEGF helped increase BCVA, reduce macular edema and significantly regress retinal neovascularization.