HIỆU QUẢ CỦA LỌC MÁU HẤP PHỤ BẰNG MÀNG LỌC RESIN (HA330) TRONG ĐIỀU TRỊ BỆNH NHÂN SEPSIS

Abstract

Objective: To evaluate the effect of hemoperfusion with a resin membrane (HA330) in the treatment of sepsis patients. Methods: An intervention study with a retrospective control group of 2 groups of sepsis patients treated with standard treatments according to SSC in both groups combined with hemoperfusion (HA330) in the intervention group at Phu Tho Provincial General Hospital, between January 2022 and December 2022. The primary outcome is all-cause mortality during ICU stay and at 28 days. Secondary outcomes are ICU stay, hospital stay, and changes in SOFA, APACHE II, and inflammatory marker scores between the 2 groups. Results: 86 patients included in the study were divided into 2 groups, the Hemoperfusion group (N = 46). There was no difference between the 2 groups in mortality at 28 days and ICU mortality (p > 0.05). The Hemoperfusion group (HP) had a hospital stay of 13.8 ± 0.5 days and an ICU stay of 5.3 ± 0.4 days, lower than the Control group by 16.5 ± 0.6 and 6.2 ± 0.2, respectively, with p < 0.05. The HP group had an APACHE II score on day 1 (7.4 ± 0.9); day 3 (5.2 ± 1), SOFA day 1 (4.0 ± 0.5), day 3 (3.4 ± 0.8), PCT on day 1 (9.9 ± 1.7), and day 3 (3.8 ± 0.8) were lower than the control group with indexes of 9.8 ± 1, 6.9 ± 1, 6 ± 0.6, 5.3 ± 1.1, 21.9 ± 2.03, and 18.9 ± 3.1, respectively, with p < 0.05. In the HP group, the pre-HP indices of urea (6.8 ± 0.6), creatinine (109.4 ± 8.3), GOT (45.4 ± 4.2), GPT (50.8 ± 4.4), and platelets (227.2 ± 13.3) were higher than the post-HP group with the corresponding indices: 6.4 ± 0.7; 101.8 ± 8.6; 43.0 ± 4.1; 43.5 ± 4.5; 175.8 ± 10.9, respectively, with p < 0.05. Conclusion: There was no difference in ICU and 28-day mortality between the 2 groups. The hemodialysis group was effective in improving ICU and hospital length of stay, as well as reducing APACHE II and SOFA scores at day 1 and day 3 after admission.