NGHIÊN CỨU HOẠT ĐỘ AMYLASE, LIPASE VÀ NỒNG ĐỘ C-REACTIVE PROTEIN HUYẾT THANH TRÊN BỆNH NHÂN VIÊM TỤY CẤP CÓ TĂNG TRIGLYCERIDE

Abstract

Background: Acute pancreatitis is primarily diagnosed based on acute abdominal pain and concurrent elevations in Amylase, Lipase enzyme activities, and C-reactive protein (CRP) levels in serum. Additionally, various tests are utilized to assess the severity of acute pancreatitis, with the quantification of C-reactive protein considered the standard test and holding substantial promise for the near future. Objectives: Determine the activity of Amylase, Lipase by measuring enzyme kinetics and C-reactive protein by immunoturbidity method and investigate the relationship between serum Amylase, Lipase activity and serum CRP levels in patients with acute pancreatitis have increased serum Triglyceride during treatment. Subjects and research methods: A analytical cross-sectional study was conducted on patients with definitive diagnosis of acute pancreatitis and high serum Triglyceride levels at Emergency, Gastroenterology and Biochemistry department of Cho Ray hospital, from December 2022 to October 2023. Results: We identified 75 cases of acute pancreatitis attributed to elevated serum Triglyceride. The average age of the study group was 38.72 ± 9.39 years, with males comprising 77.3%, resulting in a male:female ratio of 3.5:1. Most patients presented with grade E acute pancreatitis, accounting for 68%. Upon admission, Amylase levels increased in 82.7% of cases. However, no statistically significant correlations were observed at admission among blood concentrations of serum Amylase, CRP, Lipase, and Triglyceride. At the treatment stage, a statistically significant correlation emerged between pancreatitis severity and blood levels of serum Amylase and CRP. Conclusions: This study have demonstrated that serum Amylase and Lipase activity increased in acute pancreatitis and decreased significantly after effective treatment. Elevated serum Amylase and CRP levels were associated with severity of pancreatitis during treatment.

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