THE PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ASSOCIATED FACTORS IN ELDERLY PATIENTS WITH TYPE 2 DIABETES
Main Article Content
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a common condition in individuals with type 2 diabetes, especially among the elderly. However, in Vietnam, specific data on this population remain limited. Objective: To determine the prevalence of NAFLD and identify associated factors in elderly patients with type 2 diabetes. Methods: A cross-sectional study was conducted at the Endocrinology Outpatient Clinic, Thong Nhat Hospital, from August to December 2024. Participants were patients aged ≥60 years with type 2 diabetes. Results: Among 404 participants, the prevalence of NAFLD was 54.2%, with 37.3% having mild steatosis, 12.3% moderate, and 4.6% severe. Multivariate logistic regression analysis identified independent factors associated with the severity of NAFLD, including female sex (OR = 0.38; 95% CI: 0.23–0.63; p < 0.001), waist circumference (OR = 1.08; 95% CI: 1.03–1.12; p = 0.002), HbA1C (OR = 1.52; 95% CI: 1.21–1.90; p < 0.001), and triglyceride levels (OR = 1.39; 95% CI: 1.13–1.71; p = 0.002). Conclusion: NAFLD is highly prevalent among elderly patients with type 2 diabetes. Female sex, increased waist circumference, elevated HbA1C, and higher triglyceride levels were independently associated with greater severity of hepatic steatosis.
Article Details
Keywords
non-alcoholic fatty liver disease, type 2 diabetes, elderly
References
2. Ajmera V, Cepin S, Tesfai K, et al. A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes. Journal of hepatology. 2023/03/01/ 2023;78(3):471-478. doi:https://doi.org/10.1016/j.jhep.2022.11.010.
3. Alqahtani SA, Schattenberg JM. NAFLD in the Elderly. Clinical interventions in aging. 2021;16:1633-1649. doi:10.2147/cia.S295524.
4. Chen TP, Lai M, Lin WY, et al. Metabolic profiles and fibrosis of nonalcoholic fatty liver disease in the elderly: A community-based study. Journal of gastroenterology and hepatology. Sep 2020;35(9):1636-1643. doi:10.1111/jgh.15073.
5. Hartleb M, Barański K, Zejda J, et al. Non-alcoholic fatty liver and advanced fibrosis in the elderly: Results from a community-based Polish survey. 2017;37(11):1706-1714. doi:https://doi. org/10.1111/liv.13471.
6. Tuong TTK, Tran DK, Phu PQT, et al. Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: Evaluation of Hepatic Fibrosis and Steatosis Using Fibroscan. Diagnostics (Basel, Switzerland). Mar 14 2020;10(3)doi:10.3390/ diagnostics10030159.
7. Yamane R, Yoshioka K, Hayashi K, et al. Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus. World journal of hepatology. Jun 27 2022;14(6):1226-1234. doi:10.4254/ wjh.v14.i6.1226.
8. Younossi ZM, Golabi P, de Avila L, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis. Journal of hepatology. Oct 2019;71(4): 793-801. doi:10.1016/j.jhep.2019. 06.021.