SLEEP QUALITY AND RELATED FACTORS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Thùy Dương Lại, Thị Phương Thủy Nguyễn, Minh Tâm Dương

Main Article Content

Abstract

Background: Poor sleep quality is a common issue among patients with systemic lupus erythematosus (SLE), significantly impacting their daily activities and overall quality of life. Objectives: This study aimed to evaluate sleep quality and associated factors in patients with SLE. Methods: A cross-sectional descriptive study was conducted involving 186 SLE patients who visited and received treatment at Bach Mai Hospital from May 2024 to January 2025. Participants were interviewed using a pre-designed questionnaire and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Results: Among patients with SLE, 66.1% of patients experiened poor sleep quality, indicated by a PSQI score greater than 5. The PSQI scores in this study ranged from 0 to 20 points, with an average score of 8.36 points. Common factors contributing to poor sleep quality in these patients included waking up too early and frequent nighttime trips to the bathroom, which were the most prevalent issues reported. The sleep quality of patients with SLE was influeed by several factors, including age, educational level, disease activity of SLE, organ damage, scores from the Lupus Pro quality of life assessment, pain levels measured by the VAS scale, along with the reductions in blood complement concentration and high level of IL-6 in serum. Conclusions: The study results indicated that Vietnamese patients with SLEs had a high rate of poor sleep quality. The most common issues reported including waking up too early and needing to get up to use the bathroom. Several factors affected the sleep quality of these patients, particularly during periods of acute disease progression.

Article Details

References

Tian J, Zhang D, Yao X, Huang Y, Lu Q. Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study. Ann Rheum Dis. 2023; 82(3):351-356. doi:10.1136/ard-2022-223035
2. Palagini L, Tani C, Mauri M, et al. Sleep disorders and systemic lupus erythematosus. Lupus. 2014;23(2): 115-123. doi:10.1177/ 0961203313518623
3. Tô Minh Ngọc. Validity of the Vietnamese Version of the Pittsburgh Sleep Quality Index (V-PSQI). Vietnam J Prev Med. 2017;27(4):50-56. doi:10.5281/zenodo.13879050
4. Nguyễn Công Thắng, Nghiên cứu đặc điểm rối loạn giấc ngủ trên bệnh nhân lupus ban đỏ hệ thống điều trị tại trung tâm dị ứng miễn dịch lâm sàng BV bạch mai năm 2015. Luận Văn Y Học. February 5, 2019.
5. Sahebari M, Ravanshad S, Ravanshad Y, et al. A Survey on Sleep Disorders and Related Hormones in Patients with Newly Diagnosed Systemic Lupus Erythematosus. Mediterr J Rheumatol. 2021;32(2): 148-157. doi:10.31138/ mjr.32.2.148
6. Özer S, Kankaya H, Gün R, Yeler N, Marangoz Ö, Bozça H. Factors affecting sleep quality in patients with systemic lupus erythematosus. Lupus. 2022;31(1):39-44. doi:10. 1177/09612033211062521
7. Hong S, Mills PJ, Loredo JS, Adler KA, Dimsdale JE. The association between interleukin-6, sleep, and demographic characteristics. Brain Behav Immun. 2005;19(2): 165-172. doi:10.1016/j.bbi.2004.07.008
8. Fernandes M, Spanetta M, Vetrugno G, et al. The potential role of interleukin-6 in the association between inflammation and cognitive performance in obstructive sleep apnea. Brain Behav Immun - Health. 2024;42:100875. doi:10.1016/j.bbih.2024.100875