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EVALUATION OF THE VALUE OF HPV, PAP TEST AND CO-TESTING IN CERVICAL CANCER SCREENING
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Abstract
Objectives: To evaluate the effectiveness of HPV testing, cytology testing and co-testing in cervical cancer screening. Methods: The cross-sectional study included 319 patients who visited Hanoi Medical University Hospital from January to October 2024. All patients underwent hrHPV testing, pap test and cervical biopsies. The statistical analysis was performed using SPSS version 26.0 for Windows. Results: 10 cases (3.1%) had negative hrHPV and PAP results; 14 cases (4.4%) had negative hrHPV and PAP positive results; 149 cases (46.7%) had positive hrHPV and PAP negative results; 146 cases (45.8%) had positive results for hrHPV and PAP. The hrHPV test has a sensitivity of 92.4%, a positive predictive value of 98.3%. The pap test has a sensitivity of 51.0%, a positive predictive value of 100%. Co-testing was the best method in cervical cancer screening with the highest sensitivity (96.8%) and good accuracy (95.3%) (statistically significant difference, p < 0.01). Conclusion: HPV testing is more sensitive than cytology testing in cervical cancer screening, and co-testing should be used when the patient has the condition.
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Keywords
hrHPV, pap test, co-testing
References
2. Park IU, Wojtal N, Silverberg MJ, et al (2015). Cytology and human papillomavirus co-test results preceding incident high-grade cervical intraepithelial neoplasia. PLoS One. 2015 Mar 20;10(3):e0118938.
3. Clifford G, Franceschi S, Diaz M, et al (2006). Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine. 2006;24 Suppl 3:S3/26-S3/34.
4. Mayrand MH, Duarte-Franco E, Rodrigues I, et al (2007). Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N Engl J Med. 2007 Oct 18;357(16):1579-88. doi: 10.1056/NEJMoa071430. PMID: 17942871.
5. Trương Thị Kim Hoàn (2019). Giá trị tầm soát ung thư cổ tử cung bằng xét nghiệm PAP, HPV, phối hợp PAP và HPV (co-testing) tại Bệnh viện Phụ sản Nhi Bình Dương. Tạp chí Phụ sản. 16(04), tr88-91
6. Schiffman M, Castle PE, Jeronimo J, et al (2007). Human papillomavirus and cervical cancer. Lancet. 2007. 370 (9590):890-907.
7. Zhang D, Li T, Chen L, et al (2017). Epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in Beijing, China. PLoS One. 2017 May 22;12(5):e0178033.
8. Cuzick J, Du R, Adcock R, et al (2021). Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States. Gynecol Oncol. 2021 Sep;162(3):555-559.