OVERVIEW OF THE EFFECTIVENESS OF AUTOLOGOUS PLATELET-RICH PLASMA INJECTION THERAPY IN THE TREATMENT OF TENDINOPATHIES
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Abstract
Objectives: To synthesize current evidence on the effectiveness of platelet-rich plasma (PRP) in the treatment of tendinopathies. Subjects and Methods: A narrative review of 16 clinical studies on platelet-rich plasma (PRP) in the treatment of tendinopathies. The review analyzes study characteristics, treatment outcomes based on clinical scoring systems, and comparisons with other therapeutic approaches. Results: PRP demonstrated significant improvements in pain relief and functional outcomes, particularly for patellar tendon, rotator cuff, and plantar fascia conditions, outperforming corticosteroids and physical therapy. However, outcomes for lateral epicondylitis and Achilles tendinopathy were less consistent. A detailed, hospital-ready protocol for PRP injection was also developed, covering screening, indications, injection techniques, monitoring, and management of complications. Conclusion: PRP is a safe and promising treatment for various tendinopathies, especially when applied through a standardized protocol. Further research is needed to assess long-term efficacy and cost-effectiveness to optimize clinical application.
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Keywords
Platelet-rich plasma (PRP), tendinopathy, clinical protocol
References
2. T. Gosens, B. L. Den Oudsten, E. Fievez, P. van 't Spijker, A. Fievez (2012) "Pain and activity levels before and after platelet-rich plasma injection treatment of patellar tendinopathy: a prospective cohort study and the influence of previous treatments". Int Orthop, 36 (9), 1941-6.
3. A. Hamid MS, M. R. Mohamed Ali, A. Yusof, J. George, L. P. Lee (2014) "Platelet-rich plasma injections for the treatment of hamstring injuries: a randomized controlled trial". Am J Sports Med, 42 (10), 2410-8.
4. J. W. Hammond, R. Y. Hinton, L. A. Curl, J. M. Muriel, R. M. Lovering (2009) "Use of autologous platelet-rich plasma to treat muscle strain injuries". Am J Sports Med, 37 (6), 1135-42.
5. E. P. Palacio, R. R. Schiavetti, M. Kanematsu, T. M. Ikeda, R. R. Mizobuchi, J. A. Galbiatti (2016) "Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial". Rev Bras Ortop, 51 (1), 90-5.
6. P. Behera, M. Dhillon, S. Aggarwal, N. Marwaha, M. Prakash (2015) "Leukocyte-poor platelet-rich plasma versus bupivacaine for recalcitrant lateral epicondylar tendinopathy". J Orthop Surg (Hong Kong), 23 (1), 6-10.
7. A. K. Mishra, N. V. Skrepnik, S. G. Edwards, G. L. Jones, S. Sampson, D. A. Vermillion, et al. (2014) "Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients". Am J Sports Med, 42 (2), 463-71.
8. A. P. Boesen, R. Hansen, M. I. Boesen, P. Malliaras, H. Langberg (2017) "Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study". Am J Sports Med, 45 (9), 2034-2043.
9. T. P. Krogh, T. Ellingsen, R. Christensen, P. Jensen, U. Fredberg (2016) "Ultrasound-Guided Injection Therapy of Achilles Tendinopathy With Platelet-Rich Plasma or Saline: A Randomized, Blinded, Placebo-Controlled Trial". Am J Sports Med, 44 (8), 1990-7.
10. G. Ferrero, E. Fabbro, D. Orlandi, C. Martini, F. Lacelli, G. Serafini, et al. (2012) "Ultrasound-guided injection of platelet-rich plasma in chronic Achilles and patellar tendinopathy". J Ultrasound, 15 (4), 260-6.