KẾT QUẢ ĐIỀU TRỊ NGỘ ĐỘC N2O BẰNG PHÁC ĐỒ VITAMIN B12 PHỐI HỢP TIÊM BẮP VÀ UỐNG

Abstract

Background: Nitrous oxide (N₂O), commonly referred to as laughing gas, is widely utilized in various applications but has seen a surge in recreational misuse. This trend has resulted in increased hospitalizations due to neurological complications. A combined intramuscular and oral vitamin B₁₂ regimen, showing promise in international studies, is currently implemented at the Poison Control Center, Bach Mai Hospital, though its effectiveness requires further evaluation. Objective: To evaluate the clinical outcomes of a combined intramuscular and oral vitamin B12 regimen in treating N₂O poisoning. Methods: A descriptive study was conducted involving 35 patients diagnosed with N₂O poisoning, treated with the combined vitamin B12 regimen at the Poison Control Center, Bach Mai Hospital. Results: The median Total Neuropathy Score-clinical (TNSc) decreased from 10.7 ± 3.7 at admission to 3.2 ± 1.8 at discharge and further to 1.4 ± 0.7 after one month. Elevated homocysteine levels, observed in 82.9% of patients at admission, reduced to 12.5% after one month. Mean hemoglobin levels rose from 139.6 ± 30.1 g/L at admission to 150.4 ± 26.1 g/L after one month, while mean corpuscular volume (MCV) decreased from 89.8 ± 13.6 fL to 87.8 ± 16.3 fL over the same period. Conclusion: The combined intramuscular and oral vitamin B₁₂ regimen significantly improves clinical symptoms in patients with N₂O poisoning, as demonstrated by reductions in TNSc scores and homocysteine levels, alongside enhancements in hematological parameters.