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Date Published: 29/09/2025
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DOI: https://doi.org/10.51298/vmj.v554i1.15588
Issue
Vol. 554 No. 1 (2025)
Section
Các bài báo
How to Cite
Lý, X. Q., & Văn, T. H. H. (2025). ASSESSMENT OF SURVIVAL OUTCOMES AND PREDICTIVE FACTORS AFFECTING PROGNOSIS IN ACUTE INVASIVE FUNGAL RHINOSINUSITIS AT UNIVERSITY MEDICAL CENTER HO CHI MINH CITY. Vietnam Medical Journal, 554(1). https://doi.org/10.51298/vmj.v554i1.15588

ASSESSMENT OF SURVIVAL OUTCOMES AND PREDICTIVE FACTORS AFFECTING PROGNOSIS IN ACUTE INVASIVE FUNGAL RHINOSINUSITIS AT UNIVERSITY MEDICAL CENTER HO CHI MINH CITY

Xuân Quang Lý, Thị Hải Hà Văn

Main Article Content

Abstract

Objective: This study analyzed survival rates and prognostic factors in patients with acute invasive fungal rhinosinusitis (AIFRS) at University Medical Center Ho Chi Minh City. Method: A retrospective descriptive study of 50 AIFRS patients (2021–2023) assessed symptoms, endoscopic findings, imaging (CT/MRI), surgical methods, and antifungal therapy. Data were analyzed using SPSS 22. Results: Overall of 50 acute invasive fungal rhinosinusitis cases (78% survival, 22% mortality) found Mucormycosis (62%) more prevalent than Aspergillus. Poor prognostic factors: COVID-19 (HR=28.9), intracranial invasion (HR=65.1), and cerebral hemorrhage (HR=70.4). Multivariate analysis identified intracranial extension (HR=30.9) and COVID-19 (HR=8.8) as independent predictors of mortality. Mean survival was 74.5 days, significantly shorter in intracranial invasion (28.9 days) and COVID-19 groups (46.9 days). Conclusion: AIFRS prognosis depends on comorbidities, pathogen type, and disease extent. Diabetes and COVID-19 raised mortality risk 8.83-fold. Early diagnosis and aggressive treatment (surgery + tailored antifungals) are critical for survival.

Article Details

Keywords

Invasive fungal rhinosinusitis, Mucormycosis, Aspergillus, mortality rate, COVID-19.

References

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