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SINGLE NUCLEOTIDE POLYMORPHISM OF STAT4 GENE IN PATIENTS LUPUS NEPHRITIS
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Abstract
Objective: to study the single nucleotide polymorphism rs7582694 of STAT4 gene in patients with lupus nephritis. Methods: cross-sectional, retrospective study of 152 cases of lupus nephritis patients treated as inpatients at Bach Mai Hospital from January 2014 to February 2017. Results: The C/G genotype rate at position rs7582694 of the STAT4 in the lupus nephritis group was significantly higher than that of the control group with p<0.05. People carrying allele C had a risk of lupus nephritis twice as high as people not carrying allele C (95% CI: 1.14-3.19), with p<0.05. Patients carrying the C allele at position rs7582694 on the STAT4 gene had a 2.51-fold higher rate of anti-dsDNA antibody positivity than patients not carrying the C allele (95% CI: 1.24-5.06), p=0.008. Patients carrying the C allele had an 11.4-fold higher risk of class III renal damage than patients with class I+II damage who did not carry the C allele; with class IV-S damage being 13 times higher and IV-G damage being 8.9 times higher. Conclusion: Single nucleotide polymorphisms rs7582694 of the STAT4 gene play an important role in the pathogenesis as well as the cause of lupus nephritis.
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Keywords
: lupus nephritis, single nucleotide polymorphisms.
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