ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA NGƯỜI BỆNH WILSON TẠI TRUNG TÂM TIÊU HÓA - GAN MẬT, BỆNH VIỆN BẠCH MAI NĂM 2022 - 2025

Abstract

Objectives: To describe the clinical and paraclinical characteristics of patients with Wilson's disease at the Center for Gastroenterology and Hepatology, Bach Mai Hospital, from 2022 to 2025. Subjects and Methods: The study included 30 patients with Wilson's disease who were diagnosed and treated at the Gastroenterology and Hepatology Center. The study design was a cross-sectional study. Results: The majority of patients were between 18 and 30 years old, accounting for 73.3%, with the youngest being 18 and the oldest being 45. The male-to-female ratio was approximately 1:1. Common gastrointestinal symptoms included jaundice, edema, and ascites, with rates of 73.3%, 46.7%, and 53.3%, respectively. Neurological symptoms and other organ involvement were rare. Serum ceruloplasmin levels decreased in all 30 patients (100%), with 38.7% having levels below 5%. The 24-hour urinary copper level was measured in 12 patients, with 11 patients showing elevated levels (36.7%) and 1 patient with a non-elevated level (3.3%). Total bilirubin was elevated and serum albumin was decreased in 23 cases, accounting for 76.7%. Kayser-Fleischer rings and typical brain lesions were present in 30% and 13.3% of patients, respectively. Conclusion: Wilson's disease presents with diverse clinical manifestations and multi-organ involvement. Most patients have decreased serum ceruloplasmin levels