LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS WITH HEPATITIS B VIRUS-RELATED CIRRHOSIS
Main Article Content
Abstract
Objjectives: Study of left ventricular diastolic function by echocardiography in patients with hepatitis B virus-related cirrhosis. Patients and methods: Cross-sectional descriptive study was carried out on 68 HBV related cirrhotic patients and 30 matched subjects without a previous history of cardiac in Bach Mai Hospital from July 2020 to August 2021. All study participants underwent cardiac assessment with echocardiography, the parameters assessed included annular e’ velocity (septal e’, ateral e’), average E/e’ ratio, LA maximum volume index (LAVi ml/m2), and peak TR velocity (TRV m/s). Results: Annular e’ velocity was lower, average E/e’ ratio was higher, LAVi and TRV were higher in the HBV related cirrhotic group (p<0.01). 48.5% of patients with HBV related cirrhosis had diastolic dysfunction. Child – Pugh grade C (p<0.001), ascites (p<0.001) and INR ≥ 1.3 (p=0.001) were significant predictors of diastolic dysfunction in patients with hepatitis B virus-related cirrhosis.
Article Details
Keywords
Cirrhosis, left ventricular diastolic dysfunction
References

2. Trần Văn Huy, Nguyễn Thị Huyền Thương (2016). Nghiên cứu hiệu quả của tenofovir trên bệnh nhân xơ gan do virus viêm gan B. Tạp chí Y Dược học - Trường Đại học Y Dược Huế; 32: 25-29.

3. Izzy M, VanWagner LB, Lin G, et al. Redefining Cirrhotic Cardiomyopathy for the Modern Era. Hepatology; 2020 Jan;71(1):334–45

4. Lee RF, Glenn TK, Lee SS. Cardiac dysfunction in cirrhosis. Best Pract Res Clin Gastroenterol. 2007; 21(1): 125-40.

5. World Health Organization (2015). Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. Pp. 1-166.

6. Sarin, S. K., Kumar, M., Lau, et al (2016). Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatology international, 10(1), 1–98. https://doi.org/10.1007/s12072-015-9675-4


7. Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016; 29:277-314.

8. Yuan W., Lu, H. Z., Mei, X., et al (2019). Cardiac health in patients with hepatitis B virus-related cirrhosis. Medicine; 98(13), e14961. https://doi.org/10.1097/MD.0000000000014961

