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Date Published: 01/06/2023
Abstract Views: 455
Views PDF: 145
DOI: https://doi.org/10.51298/vmj.v526i2.5568
Issue
Vol. 526 No. 2 (2023)
Section
Các bài báo
How to Cite
Lê, T. H. ., Lý , K. V. ., Hoàng, T. M. ., & Phan , T. C. L. . (2023). COMBINATION OF BACTERIA, VIRUS IN HOSPITALIZED COMMUNITY - ACQUIRED PNEUMONIA PATIENTS. Vietnam Medical Journal, 526(2). https://doi.org/10.51298/vmj.v526i2.5568

COMBINATION OF BACTERIA, VIRUS IN HOSPITALIZED COMMUNITY - ACQUIRED PNEUMONIA PATIENTS

Thị Huệ Lê1,, Khánh Vân Lý 2, Tiến Mỹ Hoàng2, Thị Cẩm Luyến Phan 2
1 Van Lang university
2 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Background: Hospitalized community - acquired pneumonia (CAP) is a common disease that can be caused by one or more bacteria and virus in pathogenic combination. The multiplex real-time PCR is used as an optimal technique with high sensitivity and specificity to detect pathogenic agents, especially agent combination. Objects: To determine the rate of bacterial and viral combination in hospiatalized community - acquired pneumonia patients and the relationship between the combination with patient’s age and gender. Methods: Subjects were 138 samples of the sputum from CAP patients hospitalized at Nguyen Tri Phuong hospital. Before using the multiplex real-time PCR to detect pathogenic agents, these sputums were assessed for the reliability based on Barlett’s scale. Results: There were 136 cases (98.6%) detected bacterial and viral pathogens, in which the single agents were 15 cases (11.0%) with 7 cases of single bacteria (5.1%) and 8 cases of single virus (5.9%), the multiple agents were 121 cases (89.0%). The rate of combination between bacterial agents was 14.7%, between viral agents was 4.4% and between bacterial and viral agents was 69.9%. There was no statistically significant relationship between the ratio of the pathogenic agent combination with the age group and with the gender of patients (p > 0.05). Conclusions: The rate of combination between bacterial agents is 14.7%, between viral agents is 4.4% and between bacterial and viral agent is 69.9%. There is no statistically significant relationship between the ratio of the pathogenic agent combination with the age group and with the gender of patients (p > 0.05).

Article Details

Keywords

Hospitalized community - acquired pneumonia, combination of bacterial and viral agent.

References

1. Phạm Hùng Vân, Nguyễn Văn Thành và cộng sự (2018), “Tác nhân vi sinh gây viêm phổi cộng đồng phải nhập viện – Kết quả nghiên cứu REAL 2016-2017”, Thời sự Y Học, tháng 03/2018, tr. 51-63.
2. Bộ Y tế (2018), Niên giám thống kê y tế, Hà Nội.
3. Liu Y., Chen M., et al (2009), “Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population”, BMC infectious diseases, 9(1), pp.1-9.
4. Phạm Hùng Vân (2018), “Tác nhân vi sinh gây nhiễm trùng hô hấp dưới cộng đồng cấp tính không nhập viện - Kết quả bước đầu từ nghiên cứu EACRI (Việt Nam)”, Tạp chí Hô Hấp, (15), tr. 41-55.
5. Capelastegui A., Espana P.P., et al (2012), “Etiology of community-acquired pneumonia in a population-based study: link between etiology and patients characteristics, process-of-care, clinical evolution and outcomes”, BMC Infectious Diseases, 12(1), pp. 1-9.
6. Fukushima E.A., Bhargava A. (2021), “Unusual case of necrotizing pneumonia caused by Fusobacterium nucleatum complicating influenza a virus infection”, Anaerobe, 69, 102342.
7. Jung H.S., Kang B.J., et al (2017), “Elucidation of bacterial pneumonia-causing pathogens in patients with respiratory viral infection”, Tuberculosis and respiratory diseases, 80(4), pp. 358-367.
8. Mannino D.M., Davis K.J., et al (2009), “Chronic obstructive pulmonary disease and hospitalizations for pneumonia in a US cohort”, Respir Med, 103(2), pp. 224-229.