ỨNG DỤNG ĐIỀU TRỊ TIÊU HUYẾT KHỐI ALTEPLASE CHO NGƯỜI BỆNH ĐỘT QUỴ THIẾU MÁU NÃO CẤP TÍNH TẠI BỆNH VIỆN ĐA KHOA TỈNH YÊN BÁI NĂM 2021

Abstract

Objectives: To evaluate the results of the application of Alteplase thrombolytic therapy for patients with acute ischemic stroke at Yen Bai Provincial General Hospital in 2020. Methods: The study analyzed over 80 patients admitted to the hospital and diagnosed with cerebral stroke, acute cerebral ischemia, in 4.5 hours from onset to drug use. The patients were given intravenous fibrinolytic drug Alteplase and monitored at the stroke unit, the intensive care unit of Yen Bai general hospital. Research results: Patients with cerebral artery injury before taking thrombolytic drugs: middle cerebral artery (86.25%), basilar artery (1.25%), other artery (12.5%) ). Post-medication assessment by changing the NIHSS score (stroke scale table) before taking the drug, the average NIHSS score of the patients was 12.89±4.9, after taking the drug 24h00 it decreased to 7.06±6.8 (p). <0.05). For the middle cerebral artery, the NIHSS score decreased from 13.3 ± 5.1 to 7.5 ± 6.7 (p<0.05), the other artery decreased from 10.4 ± 3.5 to 4.4 ± 2.2 (p<0.05). Evaluating the effectiveness of clinical recovery after treatment with the mRS scale (assessment of treatment results) showed that the good clinical outcome (mRS 0-2) reached 86.25%. The number of patients with poor clinical outcome with moderate to severe disability (mRS 3-5) was 13.75%, no patient died. Conclusion: Through the study showed: the clinical recovery effect after Alteplase thrombolytic therapy in stroke patients with good clinical outcome reached 86.25% and no patient died.