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Date Published: 30/08/2023
Abstract Views: 56
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DOI: https://doi.org/10.51298/vmj.v529i1B.6369
Issue
Vol. 529 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. N., Nguyễn, T. H., Thái, T. N., & Lê, V. T. (2023). SURVEY CHANGES OF PLASMA TNF - ALPHA, INTERLEUKIN 6 LEVELS IN PATIENTS WITH LUPUS NEPHRITIS BEFORE AND AFTER 6 MONTHS OF TREATMENT. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6369

SURVEY CHANGES OF PLASMA TNF - ALPHA, INTERLEUKIN 6 LEVELS IN PATIENTS WITH LUPUS NEPHRITIS BEFORE AND AFTER 6 MONTHS OF TREATMENT

Thị Ngọc Nguyễn1,2,, Thu Hương Nguyễn2, Thiên Nam Thái2, Việt Thắng Lê1
1 Vietnam Military Medical Academy
2 Vietnam National Children's Hospital.

Main Article Content

Abstract

Objectives: To Investigate changes in plasma TNF-alpha, IL-6 levels and its relationship with renal response in pediatric lupus nephritis before and after 6 months of treatment. Patients and Methods: Prospective description compared with the healthy children group, longitudinal follow-up of 75 patients (45 children with lupus nephritis with longitudinal follow-up after 6 months of treatment and 30 healthy children) from 9/2019 to 9/2022 at National Children's Hospital. Results: Plasma TNF-alpha, IL-6 levels after treatment were lower than before treatment, plasma TNF-alpha levels were not different from the control group, p > 0.05. The level of plasma IL-6 after treatment was lower than before, but still higher than the control group, p<0.001. The levels of TNF-alpha, IL-6 have predictive values ​​in pediatric lupus nephritis who do not renal response, with AUC: 0.764; 0.901, p< 0.001. Conclusion: The plasma levels of TNF alpha and IL6 after treatment decrease but do not return to normal completely, but can predict no renal response in patients with lupus nephritis.

Article Details

Keywords

Lupus nephritis, The plasma TNF-alpha, IL-6. predicting the outcome of treatment

References

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