SURVEY CHANGES OF PLASMA TNF - ALPHA, INTERLEUKIN 6 LEVELS IN PATIENTS WITH LUPUS NEPHRITIS BEFORE AND AFTER 6 MONTHS OF TREATMENT

Thị Ngọc Nguyễn1,2,, Thu Hương Nguyễn2, Thiên Nam Thái2, Việt Thắng Lê1
1 Vietnam Military Medical Academy
2 Vietnam National Children's Hospital.

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Abstract

Objectives: To Investigate changes in plasma TNF-alpha, IL-6 levels and its relationship with renal response in pediatric lupus nephritis before and after 6 months of treatment. Patients and Methods: Prospective description compared with the healthy children group, longitudinal follow-up of 75 patients (45 children with lupus nephritis with longitudinal follow-up after 6 months of treatment and 30 healthy children) from 9/2019 to 9/2022 at National Children's Hospital. Results: Plasma TNF-alpha, IL-6 levels after treatment were lower than before treatment, plasma TNF-alpha levels were not different from the control group, p > 0.05. The level of plasma IL-6 after treatment was lower than before, but still higher than the control group, p<0.001. The levels of TNF-alpha, IL-6 have predictive values ​​in pediatric lupus nephritis who do not renal response, with AUC: 0.764; 0.901, p< 0.001. Conclusion: The plasma levels of TNF alpha and IL6 after treatment decrease but do not return to normal completely, but can predict no renal response in patients with lupus nephritis.

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References

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