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Date Published: 30/08/2023
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DOI: https://doi.org/10.51298/vmj.v529i1B.6423
Issue
Vol. 529 No. 1B (2023)
Section
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How to Cite
Trần, B. K. H., & Đào, V. H. (2023). EVALUATION OF LOWER ESOPHAGEAL SPHINCTER PRESSURE AND ESOPHAGEAL MOTILITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH REFLUX SYMPTOMS OF GASTROESOPHAGEAL REFLUX. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6423

EVALUATION OF LOWER ESOPHAGEAL SPHINCTER PRESSURE AND ESOPHAGEAL MOTILITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH REFLUX SYMPTOMS OF GASTROESOPHAGEAL REFLUX

Bá Khánh Hoan Trần1,, Việt Hằng Đào2,3
1 Ha Tinh Province General Hospital
2 HMU
3 Gastroenterology - Hepatobiliary Research and Training Institute

Main Article Content

Abstract

Objectives: The study investigates the lower esophageal sphincter characteristics and esophageal motility performed by high-resolution manometry (HRM) in type 2 diabetes mellitus patients with gastroesophageal reflux symptoms. Subjects: 62 patients with reflux symptoms (including 31 type 2 diabetes patients and 31 patients without diabetes). Results: The median of the upper esophageal sphincter (UES) pressure, resting pressure of lower esophageal sphincter (LES), and 4-s integrated relaxation pressure (IRP4s) in the diabetes patients’ group were lower significantly than patients without diabetes (p<0,05). The percentage of esophageal motility disorder in diabetes patients was significantly higher than in the group of patients without diabetes; with 71,0% and 41,9% respectively (p < 0,05). In type 2 diabetes group, patients with HbA1c ≥ 7% had lower LES resting pressures and IRP4s compared to HbA1c < 7% patients (p < 0,05). Conclusions: Among patients with symptoms of gastroesophageal reflux symptoms, the proportion of esophageal motility disorder was higher in type 2 diabetes mellitus patients. Compared to the without diabetes group, UES pressure, LES resting pressure, and IPR4s were considerably lower in diabetes group.

Article Details

Keywords

: Gastroesophageal reflux symptoms, type 2 diabetes mellitus, HRM, LES, IRP4s

References

1. Mello M, Gyawali CP. Esophageal Manometry in Gastroesophageal Reflux Disease. Gastroenterol Clin North Am. 2014;43(1):69-87.
2. Relationships of Upper Gastrointestinal Motor and Sensory Function With Glycemic Control | Diabetes Care | American Diabetes Association. Accessed June 13, 2022.
3. Fox MR, Sweis R, Yadlapati R, et al. Chicago classification version 4.0© technical review: Update on standard high-resolution manometry protocol for the assessment of esophageal motility. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc. 2021;33(4):e14120.
4. Jones R, Junghard O, Dent J, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30(10):1030-1038.
5. Kahrilas PJ, Bredenoord AJ, Fox M, et al. The Chicago Classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc. 2015;27(2):160-174.
6. Sami S, Ragunath K. The Los Angeles Classification of Gastroesophageal Reflux Disease. Video J Encycl GI Endosc. 2013;1(1):103-104.
7. JPMA - Journal Of Pakistan Medical Association. Accessed June 15, 2022.
8. Verma. Esophageal motility dysfunction and Type 2 Diabetes Mellitus: Indian scenario. Accessed June 24, 2022.
9. Muroi K, Miyahara R, Funasaka K, et al. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus. Digestion. 2021;102(4):554-562.