NGHIÊN CỨU TÁC DỤNG ĐIỀU TRỊ CỦA KEM BERBERIN 1% TẠI CHỖ VẾT THƯƠNG MẠN TÍNH

Abstract

Objective: Aim of this study was to evaluate the effects of cream Berberin 1% on changes of chronic wound local. Subjects and method: We conducted a

controlled prospective study at the Wound Healing Center of Vietnam National Burn Hospital, from May, 2021 to April, 2022. 60 patients with chronic wounds were divided into two groups (Group A: 30 patients with chronic wounds was dressed by Slivirin 1% and Group B: 30 patients with chronic wounds was dressed by Berberin 1%). We assessed and recorded the chronic wound topical changes and the bacterial species at the chronic wound site at the time of before applying the Silvirrin 1%/ Berberin 1% and at the day

10 and day 20 of studied progress. Results: The progression of chronic wounds in the group B was better than in the groups A: Reduced exudation, inflammation at periwound; increased formation of granulation tissue and epithelial formation. Bacteria found on the wound surface were diverse in types, the highest rate was P.aeruginosa, S.aureus and K. pneumonia.The occurrence of these strains of bacteria decreased over time in both groups A and B. However, at day 20 after treatment, the proportion of positive samples in group A was higher than in group B. Conclusion: Cream Berberin 1% had antibacterial effect and stimulates the process of chronic wound healing better than Silvirin 1%.