ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ UNG THƯ TUYẾN GIÁP THỂ TỦY TẠI BỆNH VIỆN K GIAI ĐOẠN 2016-2023

Abstract

Objectives: To study clinicopathological characteristics and results of medullary thyroid carcinoma treatment at Vietnam National Cancer Hospital. Patients and methods: A descriptive study of 54 medullary thyroid carcinoma patients who were diagnosed from January 2016 to November 2023 at Vietnam National Cancer Hospital. Results: Male/female ratio was 1/1.08, mean age was 52.7±11.3. 66.7% tumors were classified as TIRADS 4 on ultrasound, and FNA gave medullary thyroid carcinoma results in 61.1% cases. Patients with stage III and IVa disease were 38.9% và 27.8%. Overall rate of lymph node metastasis was 53.7%. Most of surgical complications were transient hoarse voice (29.6%) and transient hypocalcemia (22.2%). 2 patients had local recurrence, 5 had lymph node metastasis, 2 had distant metastasis, and 1 died. The 5-year overall survival (OS) rate was 91.7% with a median of 81 months. The 5-year disease-free survival (DFS) rate was 73.1% with a median of 70.2 months. Conclusion: Medullary thyroid carcinoma is a rare endocrine malignancy and lymph node metastasis is common. Ultrasound, FNA, CEA and calcitonin play a diagnostic role. Surgery is the main treatment method, radiotherapy has an adjunctive role in high-risk cases. The 5-year OS rates (91.7%) and 5-year DFS rates are good (73.1%).