ANALYSIS OF CLINICAL CHARACTERISTICS AND RISK FACTORS FOR ANTIBIOTIC-RESISTANT K.PNEUMONIAE IN CRITICAL CARE DEPARTMENT OF HUU NGHI HOSPITAL

Thế Anh Nguyễn, Hoàng Dương Tô, Thị Chi Đinh, Tiến Dũng Phạm

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Abstract

Objectives: to describe patient characteristics and risk factors for antibiotic-resistant K.pneumoniae. Subjects: patients with K.pneumoniae treated at Critical care department of Huu Nghi Hospital from June 1, 2021 to June 30, 2022. Method: prospective, descriptive. Results: Male accounted for 90%, Average age was 81.4; 92.5% of patients on mechanical ventilation, 77.5% of patients with central venous catheters, glomerular filtration rate 43.2 ± 17.3 ml/min; pneumonia accounted for 62.5%, co-infection accounted for 37.5%. Risk factors for ESBL-producing strains: onset of infection in the ICU (3.4); mechanical ventilation for more than 7 days (2.6); patients with central venous catheterization (2.4); intravenous nutrition (2.3); hemodialysis (1.9). Conclusion: The group of elderly patients, mainly male, low glomerular filtration rate, mainly pneumonia, high rate of co-infection, have risk factors for antibiotic-resistant strains:mechanical ventilation, intervention, intravenous nutrition, dialysis.

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References

1. Liu P., Li X., et al. (2018), "Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection: A Meta-Analysis", Microb Drug Resist, 24(2), pp. 190- 198
2. Ruiz J., Gordon M., et al. (2019), "Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients", Antimicrob Resist Infect Control, 8, pp. 38.
3. Tô Hoàng Dương (2020), Phân tích đặc điểm lâm sàng, vi sinh và hiệu quả sử dụng kháng sinh trong điều trị nhiễm khuẩn do một số chủng Gram âm giảm nhạy cảm với kháng sinh Carbapenem tại bệnh viện Hữu Nghị, đề tài cơ sở
4. Trần Nhật Minh (2019), Phân tích đặc điểm lâm sàng, vi sinh và phác đồ điều trị của nhiễm khuẩn do Klebsiella pneumoniae tại Khoa Hồi sức tích cực, Bệnh viện Bạch Mai, Khóa luận tốt nghiệp Dược sĩ, Trường Đại học Dược Hà Nội.
5. Van Loon Karlijn, Voor in ‘t holt Anne F., et al. (2018), "A Systematic Review and Meta-analyses of the Clinical Epidemiology of Carbapenem-Resistant Enterobacteriaceae", 62(1), pp. e01730-17.
6. Yuan Y., Wang J., et al. (2020), "Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections and Outcomes", Infect Drug Resist, 13, pp. 207-215.
7. Zhu Wei-Min, Yuan Zhe, et al. (2020), "Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis", Antimicrobial resistance and infection control, 9(1), pp. 23-23.