PHÂN TÍCH ĐẶC ĐIỂM VI SINH VÀ PHÁC ĐỒ ĐIỀU TRỊ NHIỄM KHUẨN DO K.PNEUMONIAE TẠI KHOA HỒI SỨC TÍCH CỰC BỆNH VIỆN HỮU NGHỊ

Abstract

Objectives: Analyze microbiological characteristics and treatment regimens for infections caused by K.pneumoniae in the Critical care department. Subjects: patients with K.pneumoniae treated at the Critical care department of Huu Nghi Hospital from June 1, 2021 to June 30, 2022. Method: prospective, descriptive. Result: respiratory specimens accounted for the most common 54.4%, ESBL positive rate of K.pneumoniae was 55.8%, and Carbapenem resistance was 19.1%, MIC value for Carbapenem was at the low level. Common empiric antibiotic regimens are: 3rd and 4th generation Cephalosporins or Piperacilline/Tazobactam in combination with Quinolones or Amiglycosides. After microbiological results are available, the rate of using Carbapenem and Colistin based regimens is about 50%. The baseline antibiotic dosing regimen is low to moderate as it must be adjusted for low glomerular filtration rate. The rate of treatment response is 70%, the survival rate is 55%. Conclusion: K.pneumoniae is mainly seen in respiratory specimens, the rate of ESBL birth and Carbapenem resistance tend to increase; reasonable basic antibiotic regimen, good response rate.