MẬT ĐỘ XƯƠNG Ở BỆNH NHÂN BỆNH PHỔI TẮC NGHẼN MẠN TÍNH THEO PHÂN NHÓM CỦA SÁNG KIẾN TOÀN CẦU VỀ BỆNH PHỔI TẮC NGHẼN MẠN TÍNH

Abstract

Background: Osteoporosis is one of the most common co-morbidities in patients with chronic obstructive pulmonary disease (COPD). Objectives: To investigate the proportion and risk factors of osteoporosis in patients with COPD at Gia Dinh People’s Hospital. Subjects and methods: Observational and cross-sectional study. Outpatients with COPD were diagnosed and classified according to GOLD 2019 criteria. Bone mineral density (BMD) was measured by dual X-ray absorptiometry (DXA) in lumbar spine and femoral neck. Osteoporosis was diagnosed when T-score ≤ -2.5. Results: Of 104 patients with COPD participating in the study, the proportions of osteoporosis measured at the lumbar spine and at femoral neck were 33.7% and 26.9%, respectively. The proportion of osteoporosis was 44.3% when measured at either the lumbar spine or femoral neck. Female (OR 6.4; CI 95% 1.3 – 32.1) and underweight status (OR 2.5; CI 95% 1.0 – 6.2) were independently associated with osteoporosis. ABCD groups according to GOLD 2019 were not associated significantly with osteoporosis (p=0,661). Conclusion: Patients with COPD had a relatively high proportion of osteoporosis, regardless of ABCD groups according to GOLD 2019. It is necessary to measure BMD by DXA in patients with COPD, especially in female and underweight patients.