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SAGITTAL ABDOMINAL DIAMETER IN DETERMINING INSULIN RESISTANCE IN NEWLY DIAGNOSED TYPE 2 DIABETES
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Abstract
Background: To determine insulin resistance in patients with type 2 diabetes using a simple clinical index has practical significance. Objectives: To investigate the relationship between sagittal abdominal diameter (SAD) and insulin resistance compared to classic anthropometric indices and initially establish the SAD cutoff point to determine insulin resistance in patients with newly diagnosed type 2 diabetes. Subjects and methods: 136 newly diagnosed type 2 diabetes patients (not yet using blood glucose-lowering drugs) at the National Endocrinology Hospital were evaluated on: 1/ anthropometric indexes: body mass index ( BMI), waist circumference (WC), waist to hip ratio (WHR) and SAD; 2/insulin resistance index HOMA2-IR. Results: The patients with insulin resistance (HOMA2-IR ≥ 1.14) had statistically significantly higher SAD than the ones without insulin resistance (HOMA2-IR < 1.14) in both men and women. SAD has a statistically significant positive correlation with HOMA2-IR in men and women with r correlations of 0.442 (p < 0.001) and 0.672 (p < 0.001) respectively, while BMI, WC and WHR have no significant correlation with HOMA2-IR. The area under the curve of SAD in determining insulin resistance (95% confidence interval) in men and women was 0.683 (0.556 – 0.855) and 0.724 (0.592 – 0.809), respectively. The SAD cutoff point of 19.0cm in women and 20.5cm in men had a sensitivity of 76.5% and 73.7%, respectively, and a specificity of 48.4% and 59.1%, respectively, in determining insulin resistance. Conclusions: SAD has a fairly strong positive correlation with HOMA2-IR and can be used to determine insulin resistance in patients with type 2 diabetes.
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Keywords
sagittal abdominal diameter, insulin resistance, type 2 diabetes
References
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