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EVALUATION OF THE ABNORMAL KARYOTYPE CHARACTERISTICS IN MALE INFERTILITY DUE TO AZF MICRODELETIONS
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Abstract
Objectives: This study aimed to evaluation of the abnormal karyotype characteristics in male infertility due to AZF microdeletions. Materials and method: a retrospective descriptive study at the Military Institute of Clinical Embryology and Histology and the Andrology and Fertility Hospital of Hanoi on 153 men with severe oligospermia and azoospermia caused by AZF microdeletions, collecting clinical manifestations and karyotype results. Results: 35 patients with abnormalities in the karyotype were detected in one having AZF microdeletions, accounting for 22.87%; Abnormalities are located on both autosomal and sex chromosomes. In particular, rare syndromes were discovered, such as Klinefelter (47,XXY) and De la Chapelle (men 46,XX) with 5 and 2 patients, respectively; these are severe abnormalities with manifestations of azoospermia encountered in all 7 patients. Conclusion: Chromosomal abnormalities are common in infertile men affected by AZF microdeletions.
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Keywords
AZF microdeletions, karyotype, Klinefelter, De la Chapelle
References
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