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Date Published: 16/06/2024
Abstract Views: 81
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DOI: https://doi.org/10.51298/vmj.v539i3.10157
Issue
Vol. 539 No. 3 (2024)
Section
Các bài báo
How to Cite
Lê , V. H., Nguyễn , V. N., & Vũ , N. Định. (2024). INVESTIGATION ON CHANGES IN SERUM CONCENTRATIONS OF SOME INFLAMMATION MARKER TO DETERMINE BIOCOMPATIBILITY OF ZK60 IMPLANTS IN EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 539(3). https://doi.org/10.51298/vmj.v539i3.10157

INVESTIGATION ON CHANGES IN SERUM CONCENTRATIONS OF SOME INFLAMMATION MARKER TO DETERMINE BIOCOMPATIBILITY OF ZK60 IMPLANTS IN EXPERIMENTAL ANIMALS

Văn Hải Lê 1,, Việt Nam Nguyễn 2, Nhất Định Vũ 1
1 Military Hospital 103, Vietnam Military Medical University
2 108 Military Central Hospital

Main Article Content

Abstract

Objective: to investigate biocompatibility of ZK60 implants by determining serum concentrations of TNF-α, IL-1β and IL-6 in experimental animals. Methods: 45 rabbits were divided into 3 groups and implanted by titanium or HA coated or uncoated ZK60 implants. Serum concentrations of TNF-α, IL-1β and IL-6 of rabbits in all groups were measured before and after 7 days and 30 days of treatments. Results: At the 3rd day after treatments, serum concentrations of TNF-α, IL-1β increased significantly in all experimental groups. Especially, at this time, serum concentration of TNF-α, IL-1β in rats implanted with HA coated ZK60 was significantly higher than these in rats implanted with HA uncoated ZK60 and Titan. There were no significant differences in serum concentrations of IL-6 of rabbits between before and after treatments in all groups. Conclusion: HA coated and uncoated ZK60 implants had high biocompatibility.

Article Details

Keywords

ZK60 implants, biocompatibility, rabbit

References

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