KẾT QUẢ SỬ DỤNG KẾT HỢP MIFEPRISTONE VÀ MISOPROSTOLE TRONG PHÁ THAI NỘI KHOA Ở TUỔI THAI 17 ĐẾN 22 TUẦN TẠI BỆNH VIỆN PHỤ SẢN HÀ NỘI

Abstract

Objective: Review the results of combined use of Mifepristone and Misoprostole in termination of pregnancy at a gestational age from 17 to 22 weeks at Hanoi Obstetric Hospital. Materials and method: A cross-sectional study was conducted on 65 pregnant with gestational age from 17 to 22 weeks whose pregnancies terminated with the combination of Mifepristone and Misoprostole at Hanoi Obstetrics Hospital from January to June 2023. Results: The average age of the study subjects was 28.02 years with 55.4% of the cases having no children and 72.3% of the women having never had a termination of pregnancy before. The most common gestational age at which pregnancy termination is indicated in the study, and that is from 17 to 18 weeks (36.8%). The successful termination of pregnancy rate reached 95.4%, with the majority of women under 25 and from 25 - 35 years old having rate of 95.8% and 100%, respectively. The successful pregnancy termination rate reaches 91.7% at the gestational age of 17 - 18 weeks, 92.3% at 18 – 19 weeks, and 100% at gestational age from 19 - 22 weeks. Women who have 2 children have a successful termination of pregnancy rate of 81.8%, and the rate is 97.2% for women who have never had children. This rate is 100% for women who have 1 or ≥ 3 children. Up to 88.7% of miscarriages occurred within the first 24 hours after taking MSP in the combination regimen. The average time to miscarriage was 11.17 hours with a mean MSP dose of 1070.37mcg. Conclusion: The combination regimen of Mifepristone and Misoprostole in terminating pregnancy in pregnant women with a gestational age of 17 - 22 weeks is highly effective, accounting for 95.4%, especially for young pregnant women under 35 years old, and can be applied to all women in the study. The miscarriage rate within 24 hours after using MSP reached 88.7%.