ĐÁNH GIÁ TÁC DỤNG CỦA NANO ALGINATE/CHITOSAN/LOVASTATIN LÊN RỐI LOẠN CHUYỂN HÓA LIPID TRÊN CHUỘT CỐNG GÂY MÔ HÌNH BÉO PHÌ

Abstract

Objectives: Evaluate of the effect of improving lipid metabolism disorders of Alginate/Chitosan/Lovastatin nano in obese white rats by high-fat diet. Subjects and methods: The 72 white male rats were divided into two groups of normal diet (n = 36) and high-fat diet group (n = 36). After the 7-week of obesity model, these rats were randomly divided into 6 groups including 1) nomal diet-salt water (C-NaCl) group, 2) nomal diet-lovastatin dose group 4 mg/kg (C-Lovastatin), 3) nomal diet- Alginate/Chitosan//Lovastatin nanocomposite 4 mg/kg (C-Nano/Lovastatin); 4) high-fat diet-salt water (B-NaCl), 5) high-fat diet-lovastatin dose of 4 mg/kg (B-Lovastatin) and 6) high-fat diet-Alginate/Chitosan/Lovastatin nano combination at dose 4 mg/kg (B-Nano/Lovastatin). The intervention period is 12 weeks. Weight measurement,  examination of triglyceride and blood cholesterol levels every 3 weeks, HDL -C and LDL – C before  and  after  12  weeks of  intervention. Results: About  the  concentration of  blood  lipid components: The groups of rats with the normal diet did not have any difference in the concentration of blood lipid components. Meanwhile, groups of rats on a high-fat diet (B - NaCl, B-Lovastatin and B-Nano/Lovastatin) had different concentrations of triglycerides and blood cholesterol (p < 0.05), in which group B-Nano/ Lovastatin reduced the concentration of Triglyceride, Cholesterol from the end of week 6 to the end of week 12 more than the B-NaCl group (p < 0.05), the B-Lovastatin group reduced the concentration of Triglyceride, Cholesterol more than from the end of week 9 compared with the B-NaCl group (p < 0.05), there was no difference between the B-Nano/ Lovastatin group and B-Lovastatin with (p > 0.05); There was no difference in plasma HDL-C and LDL-C concentrations (p > 0.05). About body weight: In the normal diet, there was usually no difference between the groups. In the high-fat diet, the B-NaCl group tended to gain weight fastest, the B-Lovastatin group and the slowlest increase was the B-Nano/Lovastatin group, but there was no difference (p > 0.05). Conclusion: This study results showed that the alginate/chitosan/lovastatin increases the effect of Lovastatin in the treatment of dyslipidemia in the animals model.