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Date Published: 11/09/2021
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DOI: https://doi.org/10.51298/vmj.v505i1.1024
Issue
Vol. 505 No. 1 (2021)
Section
Các bài báo
How to Cite
Hùng Cường, N. ., & Đăng Tiến, N. . (2021). ISOLATION AND IDENTIFICATION OF THE SYNTHETIC CANNABINOID 5-FLUORO-MDMB-PICA IN CRIMINAL EVIDENCES IN VIETNAM IN THE PERIOD OF 2018 – 2020. Vietnam Medical Journal, 505(1). https://doi.org/10.51298/vmj.v505i1.1024

ISOLATION AND IDENTIFICATION OF THE SYNTHETIC CANNABINOID 5-FLUORO-MDMB-PICA IN CRIMINAL EVIDENCES IN VIETNAM IN THE PERIOD OF 2018 – 2020

Nguyễn Hùng Cường1,, Nguyễn Đăng Tiến2
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 National Institute of Criminal Sciences

Main Article Content

Abstract

Objectives: Isolation, purification, and structural elucidation of 5 - FLUORO - MDMB – PICA compound to be used as a reference standard. Methods: Synthetic cannabis samples contained in American grass collected in criminal cases in Vietnam from 2018 to 2020, were rapidly hot-extracted with dichloromethane at 40oC to obtain total dichloromethane extract. Then, the total dichloromethane extract was separated by column chromatography to collect 5 - FLUORO - MDMB - PICA. Results: 0,9 g of 5 - FLUORO - MDMB - PICA was collected from 10 g of total dichloromethane extract with the purity of 99,46%. The structure of 5 - FLUORO - MDMB - PICA compound was elucidated by analytical methods TLC, IR, UV, GC-MS, LC-MS, NMR. Conclusions: In the study, 5-FLUORO-MDMB-PICA compound has been successfully isolated, purified, and structural elucidated. The compound could be potentially used as a reference standard for testing and assessing synthetic cannabis samples, meeting the requirements of investigating drug crimes in Vietnam.

Article Details

Keywords

Synthetic cannabinoids, , 5 - FLUORO - MDMB - PICA, column chromatography, HPLC-PDA

References

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