NGHIÊN CỨU MỨC ĐỘ BIỂU HIỆN GEN A20 Ở BỆNH NHÂN U LYMPHO ÁC TÍNH KHÔNG HODGKIN

Abstract

Objective: Determine the mRNA expression level of A20 in NHL patients. Evaluate the relationship between mRNA expression level of A20 and some clinical, subclinical characteristics in NHL patients. Methods: 83 patients were diagnosed with NHL and 83 healthy people as a control group. Quantitative RT-PCR was used to analyze mRNA expression of A20. Results: The average age of the NHL patient group was 56.4 ± 16.1 years. The highest age is 86 years old, the lowest age is 17 years old. The percentage of age group ≤ 60 and over 60 is 51.8% and 48.2%, respectively. Stage (I and II) is 41% and 59% is stage (III and IV). Aggressive lymphoma group account for 84.3% and only 15.7% in indolent group. The mRNA expression level of A20  in the NHL patient group is lower than the control group with P < 0.05. The mRNA expression level of A20 is moderately negatively correlated with β2-Microglobulin concentration with statistical significance (rs= -0.31, p = 0.005).There is no statistically significant in the mRNA expression level of A20 with age, stage, progression group and some subclinical characteristics in patients with NHL. Conclusion: The  mRNA expression level of A20 in the NHL patient group is lower than the control group and moderately inversely correlated with β2-Microglobulin concentration, has statistically significant. There is no statistically significant relationship between the mRNA expression level of A20 and some clinical, subclinical in NHL patients.