TÌNH HÌNH KHÁNG KHÁNG SINH CỦA CÁC CHỦNG STENOTROPHOMONAS MALTOPHILIA PHÂN LẬP TẠI BỆNH VIỆN ĐA KHOA TỈNH BẮC NINH 2019-2023

Abstract

Stenotrophomonas maltophilia represents a significant pathogenic threat, with increasing instances of antibiotic resistance among its strains. Method: This cross-sectional descriptive study endeavours to elucidate the epidemiological characteristics and antibiotic resistance profiles of S. maltophilia strains isolated at a provincial general hospital in Bac Ninh during the period from 2019 to 2023. Results: Of the 42 isolated strains, 59.5% were obtained from patients aged ≥60 years, 54.8% from males, 76.2% from Internal Medicine departments, and 73.8% from blood specimens. The resistance rates of S. maltophilia strains to Levofloxacin (LVX) and Trimethoprim-Sulfamethoxazole (SXT) were 5.7% and 11.9%, respectively. Notably, Intensive Care Units (ICUs) exhibited the highest rate of isolation of S. maltophilia strains resistant to antibiotics. Furthermore, strains resistant to LVX demonstrated universal resistance to SXT. Conclusions: the findings underscore the importance of exercising caution when utilizing LVX for treating infections caused by S. maltophilia. The study underscores the importance of prioritizing ongoing monitoring of antibiotic resistance and implementing robust infection control measures, not only to enhance treatment efficacy but also to mitigate the dissemination of resistant bacterial strains.