NỒNG ĐỘ D-DIMER Ở BỆNH NHÂN COVID-19 TRUNG BÌNH VÀ NẶNG ĐIỀU TRỊ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG GIAI ĐOẠN 2021-2023

Abstract

A retrospective study on 214 moderate and severe COVID-19 patients over 18 years old admitted to the National Hospital for Tropical Diseases from 2021 to 2023 to evaluate D-dimer levels at admission and during the treatment period. Results: At admission, the median D-dimer levels were higher than normal range in all patients. In the moderate COVID-19 group, there was no significant difference of D-dimer levels on day 3, 7 and 14 when compaired to at admission day. Otherwise, in the severe group, D-dimer levels increased on day 7 and were significantly higher on day 14 compaired to at admission: 1637 ng/mL (IQR 849–3968.8) versus 1170.5 ng/mL (IQR 605–2573), p<0.001. On day 7 and 14, D-dimer levels in the severe group were significantly higher than that in the moderate group: 1549 ng/mL (IQR 983.5- 2609.5) versus 1138 ng/mL (IQR 609.3 – 1858), p<0.01 and 1637 ng/ml (IQR 849-3968.8) versus 1020 ng/mL (IQR 521-1830), p<0,001; respectively. The rate of patients who had simultaneously thrombopenia and D-dimer exceeding 2500 ng/mL in the clinical deterioration group was higher than that in the non-clinical deterioration group (16.7% versus 6.8%, p<0.05). Conclusion: High elevation of D-dimer levels were associated with the severity of COVID-19 patients, especially on day 7 and 14 after hospital admission.