Article Sidebar

PDF
Date Published: 11/09/2021
Abstract Views: 383
Views PDF: 217
DOI: https://doi.org/10.51298/vmj.v505i1.1032
Issue
Vol. 505 No. 1 (2021)
Section
Các bài báo
How to Cite
Thị Thu Trang, L. ., Thị Hải Yến, T. ., & Quốc Ánh, V. . (2021). OPPORTUNITIES AND CHALLENGES OF FUSED DEPOSITION MODELING 3D PRINTING TECHNOLOGY IN PHARMACEUTICAL FORMULATION DEVELOPMENT. Vietnam Medical Journal, 505(1). https://doi.org/10.51298/vmj.v505i1.1032

OPPORTUNITIES AND CHALLENGES OF FUSED DEPOSITION MODELING 3D PRINTING TECHNOLOGY IN PHARMACEUTICAL FORMULATION DEVELOPMENT

Lê Thị Thu Trang1, Trần Thị Hải Yến1, Võ Quốc Ánh1,
1 Hanoi University of Pharmacy

Main Article Content

Abstract

Fused deposition modeling (FDM) is currently the most popular additive manufacturing technology owing to its flexibility, low cost and ease of use. This technology can fabricate complex objects as well as flexibly customize dosage forms satisfying treatment needs of patients. Numerous polymer excipients have been studied that offer a wide range of choices for various pharmaceutical dosage forms such as control release, multi API loaded pills, intragastric floating drug delivery systems. However, this emerging technology also faces many challenges related to print quality issues, intellectual property and lack of regulatory guidelines when it comes to the industry.

Article Details

Keywords

Three-dimension (3D) printing, 3D printed drugs, fused deposition modeling, material extrusion

References

1. Pacurariu, A.C., Straus, S.M., Trifiro, G., Schuemie, M.J., Gini, R., Herings, R., Mazzaglia, G., Picelli, G., Scotti, L., and Pedersen, L. (2015). Useful interplay between spontaneous ADR reports and electronic healthcare records in signal detection. Drug safety 38, 1201-1210.
2. Procopio, A.a.T., D. (2020). Opportunities and challenges of 3D-printed pharmaceutical dosage forms. In Drug Delivery Trends, 15-44.
3. Chen, G., Yihua, X., Kwok, P., & Kang, L. (2020). "Pharmaceutical applications of 3D printing". Additive Manufacturing, , 101209.
4. Isreb, A., et al. (2019). "3D printed oral theophylline doses with innovative ‘radiator-like’design: Impact of polyethylene oxide (PEO) molecular weight.". International journal of pharmaceutics. 564, 98-105.
5. Gioumouxouzis, C.I., et al. (2018). "A 3D printed bilayer oral solid dosage form combining metformin for prolonged and glimepiride for immediate drug delivery.". European Journal of Pharmaceutical Sciences, 120, 40-52.
6. Vo, A.Q., et al (2020). "Hot melt extrusion paired fused deposition modeling 3D printing to develop hydroxypropyl cellulose based floating tablets of cinnarizine." Carbohydrate Polymers, 246
7. Di Prima, M., Coburn, J., Hwang, D., Kelly, J., Khairuzzaman, A., and Ricles, L. (2016). Additively manufactured medical products–the FDA perspective. 3D printing in medicine 2, 1-6.
8. Khairuzzaman, A. (2018). Regulatory perspectives on 3D printing in pharmaceuticals. In 3D Printing of Pharmaceuticals. (Springer), pp. 215-236.