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SINGLE NUCLEOTIDE POLYMORPHISM RS1049174 OF NKG2D GENE RELATED EPSTEIN-BARR VIRUS IN B CELL LYMPHOMA TUMORS
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Abstract
NKG2D is an activated receptor on the surface of CD8+ T-cells and natural killer (NK) cells, playing an important role in recognizing and eliminating virus-infected and cancer. The single nucleotide polymorphism rs1049174 on the NKG2D gene impact to NK cells activation. The study aimed to evaluate the rs1049174 polymorphism on the NKG2D gene related EBV status in tumor tissue of B-cell lymphoma. The study was conducted on 234 tumor tissue of B-cell lymphoma and genotypes frequency determined on GG (29.5%), GC (50%), CC (20.5%). The allele frequency was recorded with 54.5% G and 45.5% C, respectively. Among 234 lymphoma patients, detected in 36 (15.4%) were infected with EBV and the presence of the G allele caused increased EBV status in lymphoma tissues compared to the C allele (p = 0.02). Our results suggested that the role EBV and rs1049174 can be as potential targets for immunotherapies in the future.
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Keywords
B cell lymphoma, Epstein-Barr virus, NKG2D.
References
2. Epidemiology of Lymphoid Malignancy in Asia | IntechOpen. Accessed February 17, 2024. https://www.intechopen.com/chapters/ 35769
3. Viet NH, Trung NQ, Dong LT, Trung LQ, Espinoza JL. Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma. J Cancer Res Clin Oncol. 2021;147(3):713-723. doi:10.1007/ s00432-020-03475-5
4. Strong RK, McFarland BJ. NKG2D and Related Immunoreceptors. In: Advances in Protein Chemistry. Vol 68. Cell Surface Receptors. Academic Press; 2004:281-312. doi:10.1016/ S0065-3233(04)68008-9
5. Asadi-Saghandi A, Shams A, Eslami G, Mirghanizadeh SA, Eskandari-Nasab E. Peginterferon Alfa-2a/Ribavirin treatment efficacy in chronic hepatitis C patients is related to natural killer group 2D gene rs1049174 GC polymorphism. VirusDisease. 2016;27(4):369-374. doi:10.1007/s13337-016-0349-1
6. A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers - PMC. Accessed February 17, 2024. https://www.ncbi. nlm.nih.gov/pmc/articles/PMC5172372/
7. H F, K M, H K, et al. Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. Carcinogenesis. 2008;29(2). doi:10.1093/carcin/bgm260
8. Crombie JL, LaCasce AS. Epstein Barr Virus Associated B-Cell Lymphomas and Iatrogenic Lymphoproliferative Disorders. Front Oncol. 2019;9:109. doi:10.3389/fonc.2019.00109
9. Ouyang Q, Wagner WM, Walter S, et al. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev. 2003;124(4) :477-485. doi:10.1016/s0047-6374(03)00026-5
10. Zheng W, Li H, Liu B, Wu C. Association between the SNPs in trace element-related metabolic genes and the risk of gastric cancer: a case-control study in Xianyou of China. J Genet. 2019;98:67.