ĐÁNH GIÁ HIỆU QUẢ ĐIỀU TRỊ CỦA FLUCONAZOLE TIÊM DƯỚI KẾT MẠC TRONG ĐIỀU TRỊ VIÊM LOÉT GIÁC MẠC DO NẤM TẠI BỆNH VIỆN MẮT THÁI BÌNH NĂM 2023

Abstract

Purpose: Efficacy of fluconazole subconjunctival injection as adjunctive therapy for fungal corneal ulcer at thai binh eye hospital in 2023. Materials and methods: Randomized controlled clinical trial in patients diagnosed with fungal corneal ulcers, Inpatient and outpatient treatment at the Cornea - Cornea Department, Thai Binh Eye Hospital from 01/2023 to 10/2023. Results: Study on 56 patients with 56 eyes with fungal corneal ulcers. The cure rate of 28 patients injecting 1 ml of Fluconazole 2% under the conjunctiva was 89.3% and the average treatment time was 32.38 ± 15.01 days. 28 patients in group I 64.3% and the average treatment time was 39.27 ± 11.21. Of the 28 patients in group I, visual acuity increased in 33.1%, stabilized in 47.4%, and decreased in 19.3%. Of the 57 patients in group I, visual acuity increased in 32.8%, stabilized in 25.0%, and decreased in 42.9%. Among 35 patients with subconjunctival injection, 28.6% of patients had mild pain at the injection site, 11.4% of patients had subconjunctival hemorrhage and no systemic or other local side effects were seen after injection. Conclusion: Fluconazole 2% subconjunctival injection once a day combined with a regular antifungal regimen is effective in treating fungal corneal ulcers. Especially in severe clinical cases with deep parenchymal abscesses to avoid surgical intervention in the acute phase