NGHIÊN CỨU BÀO CHẾ THUỐC ĐẶT HẠ SỐT PARACETAMOL

Abstract

Objective: (1) Formulate, process and prepare fever-reducing drug Paracetamol; (2) Evaluate sensory criteria, uniformity dosage unit, disintegration, qualitative and quantitative products. Methods: Use the melt casting method to make Paracetamol suppository. Result: After experimenting and analyzing the results, it was discovered that the appropriate ratio consist of PEG 400 being at 50%, PEG 4000 being at 20%, and Glycerin being at 30%. With the experimental results, the project obtained the substitution coefficient E = 1,04. By examining the physical attributes and comparing it to the theoretical formula, the final product consisted characteristic traits of white color appearance, uniformity, and no odor which all satisfies the criteria of the uniformity dosage unit and disintegration as according to the provisions of Viet Nam Pharmacopoeia IV. In addition, qualitative product from thin layer chromatography R_f = 0,44 (Methanol and Chloroform at 1:15 respectively). In continuation, quantification of Paracetamol by UV-Vis spectrophotometry method after three experiments resulted in 98,41%, 98,50%, and 98,39%, which again satisfies the criteria of uniformity dosage unit according to Viet Nam Pharmacopoeia IV