KẾT QUẢ ĐIỀU TRỊ XẠ TRỊ NÃO – TRỤC THẦN KINH SAU PHẪU THUẬT U NGUYÊN BÀO TỦY TẠI BỆNH VIỆN CHỢ RẪY

Abstract

Purpose: Evaluating the results of of craniospinal irradiation after surgery in medulloblastoma at Cho Ray hospital. Materials and methods: Retrospective study of 31 surgically treated medulloblastoma patients who received craniospinal irradiation at Radiation department – Cho Ray Cancer Center from January 1, 2018 to December 31, 2023 (6 years). Results: The male/female ratio is 1.38, children ≤ 16 years old account for 67.7%. The most common tumor location is in the cerebellum (accounting for 65%), the fourth ventricle (26%). The average tumor size is 4.7 ± 0.9 cm (2.5 – 7 cm). 61% had gross total resection, 29% had near total resection, and 10% had partial resection. Median PFS was 53.4 ± 5.7 months, 1-year PFS was 83.4%, 2-year was 70.8%, 3-year was 66.1%, 4-year was 60.6%, and 5-year was 60 .6%. Median OS was 58 ± 5.3 months, 1-year OS was 90.1%, 2-year was 74.3%, 3-year was 69.3%, 4-year was 69.3% and 5-year was 69.3%. The difference between gross total resection and near total resection is not statistically significant in both PFS and OS. The difference is statistically significant when compared to partial resection (p=0.001). Conclusion: Combining surgery and post-operative craniospinal irradiation brings very positive results in the treatment of medulloblastoma.