NGHIÊN CỨU SỰ TIẾT MEN KHÁNG BETA-LACTAM CỦA TRỰC KHUẨN GRAM ÂM TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ NĂM 2023-2024

Abstract

Background: Beta-lactamases are enzymes capable of decomposing most Beta-lactam antibiotics, including carbapenem. Gram-negative beta-lactamase-producing bacilli have spread throughout the world, leading to many momon and life -threatening infections that are increasingly difficult or impossible to treat. Objectives:1)to determine the rates of Gram-negative bacilli product yeast ESBL, AmpC and carbapenamase. 2)extent of antibiotic resistance of Gram-negative bacilli isolated from patient samples. Materials and Methods: Cross-sectional descriptive study on 349  patients examined and treated at Can Tho Central general Hospital  from 2023 to 2024. Results: The ability of to secrete beta-lactam enzymes in this research, gram-negative bacilli yeast ESBL was 35,8%, carbapenem was 25,2% and the lowest rate was 6,9% of AmpC. The rate of resistance of gram-negative bacilli to the fluoroquinolone group and folate pathway inhibitors group are > 50%. Acinetobacter baumannii was more resistant to most antibiotics curently used in hospital than E.coli và K.pneumoniae. E.coli has low resistance to carbapenem 13,6% - 14% and amikacin 0,7%. The overall proportion of multidrug resistance gram-negative bacilli isolates was 81,4%. Conclusions: Gram-negative bacilli have a high rate of beta-lactam enzyme production and multidrug resistance.