YẾU TỐ LIÊN QUAN ĐẾN SUY GAN CẤP TRÊN NỀN BỆNH GAN MẠN TÍNH (ACLF) Ở BỆNH NHÂN XƠ GAN MẤT BÙ ĐIỀU TRỊ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

Objective: To assess the rate and the factors related to acute-on-chronic liver failure (ACLF) in patients with decompensated cirrhosis treated at National Hospital for Tropical Diseases. Methods: Cross-sectional, descriptive study in 124 patients diagnosed with decompensated cirrhosis due to chronic HBV infection. The EASL CLIF-C OFs score was used to signify ACLF grades. Result: 22 patients (17.7%) demonstrated ACLF at the time of admission and 24 patients (19.4%) developed ACLF during the follow-up period of their hospitalization. The prevalence of ACLF grade 1, grade 2 and grade 3 was 1.6%, 19.4%, and 16.1%, respectively. Univariate regression analysis showed that, hepatic encephalopathy, INR>2, AST>80UI/L, ALT>80 UI/L, total bilirubin > 102.5 µmol/L, MELD-Na 1 point increment were associated with the development of ACLF in cirrhosis patients during hospitalization (p<0.05). The result of multivariate regression analysis found that INR > 2 (OR = 5.018; p = 0.036) was an independent factor associated with the occurrence of ACLF during hospitalization. Conclusion: INR was the risk factor related to ACLF in decompensated cirrhosis patients. Further research with larger sample sizes is needed for determining the independent factors associated with ACLF.