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RESEARCH OF MMP-1 CONCENTRATIONS IN THE PLASMA OF PREECLAMPTIC PREGNANT WOMEN
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Abstract
Objectives: Complete the technical process for determining the concentration of MMP-1 in the plasma of healthy pregnant women and pre-eclamptic women; to detect the association between MMP-1 concentration and some biochemical indicators in pre-eclampsia. Subjects and methods: The study was conducted on two groups of pregnant women, including 120 healthy pregnant women (control group) and 120 preeclamptic women (patient group) at Hanoi Obstetrics and Gynecology Hospital. The concentration of MMP-1 was determined by the quantitative ELISA technique. Results: The average plasma concentrations of MMP-1 in the control and patient groups were 2,92 ± 0,9 and 3,9 ± 3,22 (ng/ml), respectively. The concentration of plasma MMP-1 of the patient group is higher than that of the control group, and the difference is statistically significant with p = 0,002. There is a relationship between the concentration of MMP-1 in plasma and serum creatinine, uric acid levels in preeclamptic women. Conclusion: Using 1/10 diluted plasma to quantify the concentration of plasma MMP-1 of pregnant women with pre-eclampsia is higher than that of healthy pregnant women.
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Keywords
Pre-eclampsia, Matrix Metalloproteinase (MMP), MMP-1
References
2. Timokhina E, Strizhakov A, Ibragimova S, et al. Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia. J Pregnancy. 2020;2020: e8369645. doi:10.1155/ 2020/8369645
3. World Health Organization. WHO Recommendations for Prevention and Treatment of Pre-Eclampsia and Eclampsia. WHO; 2011.
4. Lê Thiện Thái. Nghiên Cứu Ảnh Hưởng Của Bệnh Lý Tiền Sản Giật Lên Thai Phụ và Thai Nhi và Đánh Giá Hiệu Quả Của Phác Đồ Điều Trị. Luận án Tiến sỹ Y học. Trường Đại học Y Hà Nội; 2010.
5. Trần Thị Hiền. So Sánh Thái Độ Xử Trí Tiền Sản Giật Trong Năm 2008 và Năm 2013 Tại Bệnh Viện Phụ Sản Trung Ương. Luận văn Bác sĩ chuyên khoa cấp II. Trường Đại học Y Hà Nội; 2014.
6. Nikolov A, Popovski N, Blazhev AP, Blazheva S. Comparison of Serum Levels of Collagen Type I Turnover Markers in Early-Onset Preeclampsia and Healthy Pregnant Women. Folia Med (Plovdiv). 2021;4(63):519-526.
7. Gupta M, Chari S. Assessment of Matrix Metalloproteinase-1 and its Tissue Inhibitor of Metalloproteinase-1 in Pre-eclampsia. Int J Sci Study. 2016;3(11). doi:10.17354/ijss/2016/59
8. Estrada-Gutierrez G, Cappello RE, Mishra N, Romero R, Strauss JF, Walsh SW. Increased Expression of Matrix Metalloproteinase-1 in Systemic Vessels of Preeclamptic Women: A Critical Mediator of Vascular Dysfunction. Am J Pathol. 2011;178(1): 451-460. doi:10.1016/ j.ajpath.2010.11.003