CHARACTERISTICS OF CLINICAL, ENDOSCOPIC, HISTOPATHOLOGIC AND HELICOBACTER PYLORI INFECTION IN PATIENTS WITH GASTRIC CANCER

Phạm Hồng Khánh1, Trần Thị Huyền Trang2, Nguyễn Quang Duật1, Vũ Văn Khiên2,
1 Military Hospital 103, Vietnam Military Medical University
2 108 Military Central Hospital

Main Article Content

Abstract

Introduction: Stomach cancer remains an important cancer worldwide and is responsible for over one million new cases in 2020 and an estimated 769.000 deaths, ranking fifth for incidence and fourth for mortality globally. Objectives: To study the clinical, endoscopic, histopathological and H. pylori characteristics in patients with gastric cancer. Patient & methds: 129 patients with gastric cancer were confirmed on endoscopy and histopathology. Clinicopathological features based on Borrmann's classification. Histopathological features based on Lauren's classification. Diagnosis of H. pylori infection is based on: CLO test, histopathology and culture. Results: General characteristics: Age ≧ 60 years old (67.7%), mean age: 63.8±11.9 (29-92). Clinical: Epigastric pain (97.7%), bloating (88.4%), anorexia (82.2%), weight loss (39.5%). Tumor location: antrum (48.1%), body (17%), cardia (6.2%). Histopathology: Intestinal type (55.4%), diffuse type (40.8%) and mixed (3.8%). The rate of H. pylori infection in gastric cancer patients were: 77/129 (59.2%). Conclusion: The rate of H. pylori infection in gastric cancer patients were: 77/129 (59.2%)

Article Details

References

1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71: 209-249.
2. Yamaoka Y. Mechanisms of disease: Helicobacter pylori virulence factors. Nat Rev Gastroenterol Hepatol. 2010;7(11): 629-641.
3. Mai Hồng Bàng. Đặc điểm lâm sàng, hình ảnh nội soi và mô bệnh học của ung thư dạ dày. Tạp chí Y học thực hành, 2006;3: 8
4. Nguyễn Ngọc Ánh, Nguyễn Khánh Trạch, Trần Văn Hợp. Góp phần đánh giá tình trạng nhiễm helicobacter trong bệnh lý ung thư dạ dày. Hội Nội Khoa Việt Nam, 1999;2:
5. Trần Đình Trí. Nghiên cứu đặc điểm nội soi, mô bệnh học, các týp cagA, vacA của Helicobacter pylori và tính đa hình của IL-1β, IL-1RN, IL-8, TNF-α ở bệnh nhân ung thư dạ dày. Luận án Tiến sỹ Y học- Hà Nội 2017
6. Lagergrena F, Xiea SH, Mattssona F, Lagergrena J. Updated incidence trends in cardia and non-cardia gastric adenocarcinoma in Sweden. Acta Oncologica 2018;57(9): 1173-1178
7. Wanebo HJ, Kennedy BJ, Chmiel J, et al. Cancer of the stomach. A patient care study by the American College of Surgeons. Annals of Surgery, 1993;218 (5): 583-592.
8. An JY, Kang TH, Choi MG, et al. Borrmann type IV: an independent prognostic factor for survival in gastric cancer. J Gastrointest Surg, 2008;12 (8): 1364-1369.