MỐI TƯƠNG QUAN GIỮA NỒNG ĐỘ CYSTATIN C VÀ CREATININ HUYẾT THANH TRONG BỆNH THẬN ĐÁI THÁO ĐƯỜNG

Abstract

Background: Diabetic kidney disease is the single strongest predictor of in patients with diabetes. Cystatin C is a highly regarded biomarker for measuring kidney function, aiding in the early detection of kidney damage. However, currently views differ, with the role of serum cystatin C in assessing diabetic kidney disease. Objectives: To investigate the serum cystatin c and determine the correlation between serum cystatin C and various risk factors of type 2 diabetic kidney disease. Materials and methods: A descriptive cross-sectional study on 72 patients with type 2 diabetic kidney disease treated at Can Tho University of Medicine and Pharmacy Hospital from June 2023 to April 2024. Results: A total of 72 patients were included in the study, with an average age of 68.9, predominantly female (63.9%). The average serum cystatin C concentration was 1.5 ± 0.8 mg/L. Risk factors included age, gender, underweight, duration of diabetes, hypertension, dyslipidemia, HbA1c, urine ACR were not significantly associated. Statistically significant correlation between cystatin C and smoking. There is a strong positive correlation between serum cystatin C levels and serum creatinine levels (r = 0.875; p < 0.001), as well as between eGFRcys and eGFRcre (r = 0.815; p < 0.001). Conclusion: Cystatin C has demonstrated significant potential to replace creatinine in estimating glomerular filtration rate in patients with type 2 diabetic kidney disease. These findings reinforce the role of cystatin C as an effective biomarker in assessing and managing kidney disease in diabetic patients.