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Date Published: 07/08/2024
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DOI: https://doi.org/10.51298/vmj.v541i1.10614
Issue
Vol. 541 No. 1 (2024)
Section
Các bài báo
How to Cite
Doãn, P. H., Thiều, Q. Q., Trần, B. D., Hoàng, K. L., & Tạ, A. T. (2024). THE VALUE OF THE APRI INDEX IN DIAGNOSING SEPSIS-ASSOCIATED LIVER INJURY (SALI) IN PEDIATRIC PATIENTS WITH SEPSIS. Vietnam Medical Journal, 541(1). https://doi.org/10.51298/vmj.v541i1.10614

THE VALUE OF THE APRI INDEX IN DIAGNOSING SEPSIS-ASSOCIATED LIVER INJURY (SALI) IN PEDIATRIC PATIENTS WITH SEPSIS

Phúc Hải Doãn, Quang Quân Thiều, Bá Dũng Trần, Kim Lâm Hoàng, Anh Tuấn Tạ

Main Article Content

Abstract

Objectives: In children, sepsis has a high rate of liver dysfunction (39.9%) and a high mortality rate (54% - 68% depending on the study). This study aimed to evaluate the value of the APRI index in diagnosing sepsis-associated liver injury (SALI) in patients with sepsis at the PICU, Vietnam National Children's Hospital. Subjects and methods: A descriptive study was conducted on 198 pediatric patients with sepsis in the PICU, Vietnam National Children's Hospital, from May 2022 to April 2023. Results: The SALI rate in pediatric sepsis patients was 32%. The median age of patients was 12.4 months. The boy/girl ratio was 1.9/1. The patient was admitted to the PICU with severe conditions, and the mean pSOFA score was 8.2. The rate of positive bacteria in blood and fluid cultures was 52%. The median hospital stay was 20 days. At the first 24 hours of admission to the intensive care unit, APRI was powerful in predicting SALI in children (AUC: 0.919, p<0.001) with a sensitivity of 84.1 % and a specificity of 84.2 % at the cut-off point of 0.73. The cut-off point of ARPI was 0.701, with a sensitivity of 62.3% and a specificity of 71.4% for predicting mortality in pediatric patients with sepsis. Conclusion: During the first 24 hours of admission to the PICU, the APRI index could diagnose SALI predict mortality in pediatric patients with sepsis.

Article Details

Keywords

APRI, sepsis-associated liver injury (SALI), sensitivity, specificity, children

References

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