ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA U LYMPHO NGUYÊN PHÁT THẦN KINH TRUNG ƯƠNG

Abstract

Objective: Describe clinical and para-clinical characteristics of primary CNS lymphoma; Research subjects and methods: Prospective Cross-sectional descriptive study conducted on 35 PCNSL patients treated at the Hematopoietic System Department of Hospital K from May 2019 to May 2022. Results: The average age of patients was 56.66 years; Men accounted for 54.3%; Typical clinical symptoms of primary CNS lymphoma are headache 77.1%, and hemiplegia 20%. Pathology results were diffuse large B-cell non-Hodgkin lymphoma 94.3%; activated B-cell type accounts for 74.3%; Typical Immune markers were CD20: 100%; Bcl6: 62.9%; MUM1: 62.9%; Bcl2: 11.4%, Ki67 average 78%. All patients had tumors located in the brain parenchyma. The proportion of patients with multiple brain tumors accounts for 74.3%. The highest incidence of tumors in the frontal lobe was 40%; The incidence of tumors in the occipital lobe was 25.7%; The incidence of tumors in the temporal lobe was 22.9%; The incidence of tumors in the parietal lobe was 20.0%; The incidence of tumors in the cerebellum was 11.4%. Conclusion: Primary CNS lymphoma is common in people over the age of 50, male gender, typical symptoms are headaches, may be accompanied by hemiplegia, the disease is usually large B-cell non-Hodgkin lymphoma, ABC type and often has lesions in the frontal and occipital lobes.